Sodium 4-phenylbutyrate

Also known as: Sodium phenylbutyrate, 4-Phenylbutyric acid sodium salt, SPB, 4PBA, PBNA, Phenyl n-butyrate sodium salt, Benzenebutanoic acid, sodium salt, Ammonaps, Buphenyl, Tributyrate

Sodium 4-phenylbutyrate (CAS 1716-12-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C10H11NaO2 and a molecular weight of 186.183 g/mol. Key properties include a melting point of 207 °C (dec.)(lit.), a boiling point of 290.7ºC at 760mmHg, a density of 1.095g/cm3 and a flash point of 187.9ºC. It is classified under GHS with signal word Warning and hazard statements H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1716-12-7
Jingsj CID: J-35310-2
Molecular Formula: C₁₀H₁₁NaO₂
Molecular Weight: 186.183 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	207 °C (dec.)(lit.)
Boiling Point	290.7ºC at 760mmHg
Density	1.095g/cm3
Flash Point	187.9ºC
Exact Mass	186.065674
PSA	40.13000
LogP	0.75920
Vapor Pressure	0.00288mmHg at 25°C

GHS Safety & Compliance

IrritantSignal word: Warning

H319 — Causes serious eye irritation

Activity & Biological Data

Target	HDAC
Additional Information	[1]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [2]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [3]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

Target

HDAC

Additional Information

[1]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [2]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [3]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

Customs & Trade Information

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Sodium 4-phenylbutyrate?

The CAS number of Sodium 4-phenylbutyrate is 1716-12-7.

What are the molecular formula and molecular weight of Sodium 4-phenylbutyrate?

Sodium 4-phenylbutyrate has molecular formula C10H11NaO2 and molecular weight 186.183 g/mol.

Is Sodium 4-phenylbutyrate hazardous?

Sodium 4-phenylbutyrate has GHS signal word Warning and hazard statements H319 — Causes serious eye irritation.

What are the upstream and downstream products of Sodium 4-phenylbutyrate?

For Sodium 4-phenylbutyrate, Upstream Products: 4-Phenylbutyric acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sodium 4-phenylbutyrate (CAS 1716-12-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-35310-2 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.