Thioguanine
Also known as: 6-Thioguanine, 2-Amino-6-mercaptopurine, 2-Aminopurine-6(1H)-thione, 6-Mercaptoguanine, Tioguanine, Lanvis, Tabloid, 2-Amino-1,7-dihydro-6H-purine-6-thione, 2-Amino-1H-purine-6(7H)-thione, 2-Amino-9H-purine-6(1H)-thione, 2-Amino-6-purinethiol
Thioguanine (CAS 154-42-7) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C5H5N5S and a molecular weight of 167.192 g/mol. Key properties include a melting point of ≥300 °C(lit.), a boiling point of 460.7±37.0 °C at 760 mmHg, a density of 2.1±0.1 g/cm3 and a flash point of 232.4±26.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. It is listed by 1 supplier, from 9.60 to 16.00 CNY. Record last updated Nov 3, 2026.
- CAS No.
- 154-42-7
- Jingsj CID
- J-42104-1
- Molecular Formula
- C5H5N5S
- Molecular Weight
- 167.192 g/mol
- Category
- Pharma Intermediates
- Last updated
- 11/3/2026
| Supplier | Purity / Pack | Base Price | Unit Price | Origin | |
|---|---|---|---|---|---|
Made to OrderPlatform-operated | 99% 500g | ¥4,800.00 | $1.44 /gBest ¥9.60/g CNY | CN China MOQ 500g | |
Made to OrderPlatform-operated | 99% 100g | ¥1,100.00 | $1.65 /g ¥11.00/g CNY | CN China MOQ 100g | |
Made to OrderPlatform-operated | 99% 25g | ¥400.00 | $2.39 /g ¥16.00/g CNY | CN China MOQ 25g |
Physicochemical Properties
| Melting Point | ≥300 °C(lit.) |
|---|---|
| Boiling Point | 460.7±37.0 °C at 760 mmHg |
| Density | 2.1±0.1 g/cm3 |
| Flash Point | 232.4±26.5 °C |
| Exact Mass | 167.026566 |
| PSA | 119.28000 |
| LogP | -0.99 |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| Refractive Index | 2.071 |
| Additional Property | soluble |
GHS Safety & Compliance
- H301 — Toxic if swallowed
Activity & Biological Data
| Target | IC50: 25 μM (PLpros), 40 μM (Recombinant human USP2)[3] |
|---|---|
| Additional Information | [1]. Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102. [2]. Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48(10):2290-9. [3]. LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Thioguanine?
The CAS number of Thioguanine is 154-42-7.
What are the molecular formula and molecular weight of Thioguanine?
Thioguanine has molecular formula C5H5N5S and molecular weight 167.192 g/mol.
Which suppliers offer Thioguanine?
1 supplier(s) listed; reference unit price ¥9.60–16.00 /g.
Is Thioguanine hazardous?
Thioguanine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Thioguanine (CAS 154-42-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-42104-1 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.