Verapamil hydrochloride

盐酸维拉帕米

Also known as: Verapamil HCl, (±)-Verapamil hydrochloride, Calan, Isoptin, Iproveratril, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile hydrochloride, 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride, Manidon, Vasolan

Verapamil hydrochloride (CAS 152-11-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C27H39ClN2O4 and a molecular weight of 491.063 g/mol. It is also known as Verapamil HCl, (±)-Verapamil hydrochloride and Calan. Key properties include a melting point of 142 °C (dec.)(lit.), a boiling point of 586.1ºC at 760 mmHg, a density of 1.058g/cm3 and a flash point of 308.3ºC. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H311 — Toxic in contact with skin and H331 — Toxic if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 152-11-4
Jingsj CID: J-49737-0
Molecular Formula: C₂₇H₃₉ClN₂O₄
Chinese Name: 盐酸维拉帕米
Molecular Weight: 491.063 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	142 °C (dec.)(lit.)
Boiling Point	586.1ºC at 760 mmHg
Density	1.058g/cm3
Flash Point	308.3ºC
Exact Mass	490.259827
PSA	63.95000
LogP	5.89508
Additional Property	soluble

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled

Activity & Biological Data

Target	Calcium channel[1]
Additional Information	[1]. Meister S, et al. Calcium channel blocker Verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. Neoplasia. 2010 Jul;12(7):550-61. [2]. Yanjiao X, et al. Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro. Drug Metab Pharmacokinet. 2013;28(6):468-74. [3]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567.

Target

Calcium channel[1]

Additional Information

[1]. Meister S, et al. Calcium channel blocker Verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. Neoplasia. 2010 Jul;12(7):550-61. [2]. Yanjiao X, et al. Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro. Drug Metab Pharmacokinet. 2013;28(6):468-74. [3]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567.

Customs & Trade Information

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Verapamil hydrochloride?

The CAS number of Verapamil hydrochloride is 152-11-4.

What are the molecular formula and molecular weight of Verapamil hydrochloride?

Verapamil hydrochloride has molecular formula C27H39ClN2O4 and molecular weight 491.063 g/mol.

Is Verapamil hydrochloride hazardous?

Verapamil hydrochloride has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H311 — Toxic in contact with skin; H331 — Toxic if inhaled.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Verapamil hydrochloride (CAS 152-11-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49737-0 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.