Melphalan

美法仑

Also known as: L-Phenylalanine mustard, L-PAM, 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, Alkeran, CB 3025, AT 290, Sarcoclorin, p-Di(2-chloroethyl)amino-L-phenylalanine, Melphalanum, WR 19813

Melphalan (CAS 148-82-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H18Cl2N2O2 and a molecular weight of 305.200 g/mol. It is also known as L-Phenylalanine mustard, L-PAM and 4-[Bis(2-chloroethyl)amino]-L-phenylalanine. Key properties include a melting point of ~180 °C, a boiling point of 473.1±45.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 239.9±28.7 °C. It is classified under GHS with signal word Danger and hazard statements H300, H310 and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 148-82-3
Jingsj CID: J-45087-4
Molecular Formula: C₁₃H₁₈Cl₂N₂O₂
Chinese Name: 美法仑
Molecular Weight: 305.200 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	~180 °C
Boiling Point	473.1±45.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	239.9±28.7 °C
Exact Mass	304.074524
PSA	66.56000
LogP	1.79
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.597
Additional Property	95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear \| <0.1 g/100 mL at 22 ºC

GHS Safety & Compliance

Acute Toxicity / Health HazardSignal word: Danger

H300
H310
H330 — Fatal if inhaled
H350 — May cause cancer
H361 — Suspected of damaging fertility or the unborn child

Activity & Biological Data

Target	DNA Alkylator/Crosslinker[1]
Additional Information	[1]. BLUMBERG BS, et al. AN ALKYLATING AGENT FOR MULTIPLE MYELOMA: MELPHALAN. JAMA. 1965 Feb 15;191:547-9. [2]. Glehen O, et al. Hyperthermia modifies pharmacokinetics and tissue distribution of intraperitoneal melphalan in a rat model. Cancer Chemother Pharmacol. 2004 Jul;54(1):79-84. [3]. Rothbarth J, et al. Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. Biochem Pharmacol. 2004 May 1;67(9):1771-8.

Target

DNA Alkylator/Crosslinker[1]

Additional Information

[1]. BLUMBERG BS, et al. AN ALKYLATING AGENT FOR MULTIPLE MYELOMA: MELPHALAN. JAMA. 1965 Feb 15;191:547-9. [2]. Glehen O, et al. Hyperthermia modifies pharmacokinetics and tissue distribution of intraperitoneal melphalan in a rat model. Cancer Chemother Pharmacol. 2004 Jul;54(1):79-84. [3]. Rothbarth J, et al. Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. Biochem Pharmacol. 2004 May 1;67(9):1771-8.

Customs & Trade Information

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Melphalan?

The CAS number of Melphalan is 148-82-3.

What are the molecular formula and molecular weight of Melphalan?

Melphalan has molecular formula C13H18Cl2N2O2 and molecular weight 305.200 g/mol.

Is Melphalan hazardous?

Melphalan has GHS signal word Danger and hazard statements H300; H310; H330 — Fatal if inhaled.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Melphalan (CAS 148-82-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45087-4 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.