Picolinamide
Also known as: Pyridine-2-carboxamide, 2-Picolinamide, 2-Pyridinecarboxamide, Picolinic acid amide, alpha-Picolinic acid amide, Picolinoylamide
Picolinamide (CAS 1452-77-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C6H6N2O and a molecular weight of 122.125 g/mol. Key properties include a melting point of 110 °C (dec.)(lit.), a boiling point of 257.7±32.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 109.7±25.1 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1452-77-3
- Jingsj CID
- J-1033327-9
- Molecular Formula
- C6H6N2O
- Molecular Weight
- 122.125 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 110 °C (dec.)(lit.) |
|---|---|
| Boiling Point | 257.7±32.0 °C at 760 mmHg |
| Density | 1.2±0.1 g/cm3 |
| Flash Point | 109.7±25.1 °C |
| Exact Mass | 122.048012 |
| PSA | 55.98000 |
| LogP | -0.24 |
| Vapor Pressure | 0.0±0.6 mmHg at 25°C |
| Refractive Index | 1.590 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | Poly(ADP-ribose) synthetase[1] |
|---|---|
| Additional Information | [1]. Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92. [2]. Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257(11):6084-8. [3]. Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. [4]. amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45(4):1845-9. |
Customs & Trade Information
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Picolinamide?
The CAS number of Picolinamide is 1452-77-3.
What are the molecular formula and molecular weight of Picolinamide?
Picolinamide has molecular formula C6H6N2O and molecular weight 122.125 g/mol.
Is Picolinamide hazardous?
Picolinamide has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Picolinamide (CAS 1452-77-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1033327-9 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.