Pregnenolone 16α-carbonitrile

Also known as: 16α-Cyanopregnenolone, 3β-Hydroxy-20-oxo-5-pregnen-16α-carbonitrile, 5-Pregnen-3β-ol-20-one-16α-carbonitrile, PCN, SC 4674, U-14975, Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)-, 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE, Pregnenolone-16alpha-carbonitrile, 16α-Cyano-3β-hydroxypregn-5-en-20-one, MFCD00079212, (3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile

Pregnenolone 16α-carbonitrile (CAS 1434-54-4) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C22H31NO2 and a molecular weight of 341.487 g/mol. Key properties include a boiling point of 508.5±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 261.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1434-54-4
Jingsj CID: J-3630-2
Molecular Formula: C₂₂H₃₁NO₂
Molecular Weight: 341.487 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	508.5±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	261.3±30.1 °C
Exact Mass	341.235474
PSA	61.09000
LogP	3.22
Vapor Pressure	0.0±3.0 mmHg at 25°C
Refractive Index	1.558

Activity & Biological Data

Additional Information	[1]. Yang Xie, et al. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019 Sep;70(3):995-1010. [2]. Simon Lowes, et al. The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat. Pharmaceutics. 2010 Mar 15;2(1):61-77. [3]. Jeffrey Guzelian, et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006 Dec;94(2):379-87. [4]. Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J. 2005 May 1;387(Pt 3):601-8.

Additional Information

[1]. Yang Xie, et al. Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury. Hepatology. 2019 Sep;70(3):995-1010. [2]. Simon Lowes, et al. The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat. Pharmaceutics. 2010 Mar 15;2(1):61-77. [3]. Jeffrey Guzelian, et al. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol Sci. 2006 Dec;94(2):379-87. [4]. Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J. 2005 May 1;387(Pt 3):601-8.

Frequently Asked Questions

What is the CAS number of Pregnenolone 16α-carbonitrile?

The CAS number of Pregnenolone 16α-carbonitrile is 1434-54-4.

What are the molecular formula and molecular weight of Pregnenolone 16α-carbonitrile?

Pregnenolone 16α-carbonitrile has molecular formula C22H31NO2 and molecular weight 341.487 g/mol.

What are the upstream and downstream products of Pregnenolone 16α-carbonitrile?

For Pregnenolone 16α-carbonitrile, Upstream Products: 16-Dehydropregnenolone Acetate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Pregnenolone 16α-carbonitrile (CAS 1434-54-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-3630-2 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.