Ginsenoside Rg3

人参皂苷Rg3

Also known as: 20(S)-Ginsenoside Rg3, Ginsenoside 20(S)-Rg3, 20(S)-Ginsenoside-Rg3, (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside, β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-

Ginsenoside Rg3 (CAS 14197-60-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C42H72O13 and a molecular weight of 785.013 g/mol. It is also known as 20(S)-Ginsenoside Rg3, Ginsenoside 20(S)-Rg3 and 20(S)-Ginsenoside-Rg3. Key properties include a melting point of 315-318°C, a boiling point of 885.0±65.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 489.0±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 14197-60-5
Jingsj CID: J-29812-2
Molecular Formula: C₄₂H₇₂O₁₃
Chinese Name: 人参皂苷Rg3
Molecular Weight: 785.013 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	315-318°C
Boiling Point	885.0±65.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	489.0±34.3 °C
Exact Mass	784.497314
PSA	218.99000
LogP	5.27
Vapor Pressure	0.0±0.6 mmHg at 25°C
Refractive Index	1.594
Storage Conditions	2-8°C

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	p65 COX-2 Na+ channel:32.2 μM (IC50) hKv1.4 channel:32.6 μM (IC50) Aβ40 Aβ42
Additional Information	[1]. Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na + channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42. [2]. Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26. [3]. Lee IS, et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601. [4]. Kang MS, et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82.

Target

p65 COX-2 Na+ channel:32.2 μM (IC50) hKv1.4 channel:32.6 μM (IC50) Aβ40 Aβ42

Additional Information

[1]. Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na + channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42. [2]. Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26. [3]. Lee IS, et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601. [4]. Kang MS, et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82.

Customs & Trade Information

HS Code	29214210

Frequently Asked Questions

What is the CAS number of Ginsenoside Rg3?

The CAS number of Ginsenoside Rg3 is 14197-60-5.

What are the molecular formula and molecular weight of Ginsenoside Rg3?

Ginsenoside Rg3 has molecular formula C42H72O13 and molecular weight 785.013 g/mol.

Is Ginsenoside Rg3 hazardous?

Ginsenoside Rg3 has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Ginsenoside Rg3?

For Ginsenoside Rg3, Downstream Products: 20(S)-Ginsenoside Rh2.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ginsenoside Rg3 (CAS 14197-60-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-29812-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.