Methyclothiazide

Also known as: 6-chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, Aquatensen, Enduron, 2-methyl-3-chloromethylhydrochlorothiazide, 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, Naturon, Duretic

Methyclothiazide (CAS 135-07-9) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C9H11Cl2N3O4S2 and a molecular weight of 360.237 g/mol. Key properties include a melting point of 223-225ºC, a boiling point of 597.9±60.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 315.4±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 135-07-9
Jingsj CID: J-1959225-3
Molecular Formula: C₉H₁₁Cl₂N₃O₄S₂
Molecular Weight: 360.237 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	223-225ºC
Boiling Point	597.9±60.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	315.4±32.9 °C
Exact Mass	358.956787
PSA	126.33000
LogP	1.76
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.606
Storage Conditions	-20℃

Activity & Biological Data

Target	IC50: voltage-dependent Ca-channel (VDCC)
Additional Information	[1]. Colas, B., et al., Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol, 2000. 408(1): p. 63-7. [2]. Colas, B., et al., Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol, 2000. 14(4): p. 363-8. [3]. Sasaki, S. and R.D. Bunag, Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. J Cardiovasc Pharmacol, 1983. 5(3): p. 378-83.

Target

IC50: voltage-dependent Ca-channel (VDCC)

Additional Information

[1]. Colas, B., et al., Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol, 2000. 408(1): p. 63-7. [2]. Colas, B., et al., Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol, 2000. 14(4): p. 363-8. [3]. Sasaki, S. and R.D. Bunag, Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. J Cardiovasc Pharmacol, 1983. 5(3): p. 378-83.

Frequently Asked Questions

What is the CAS number of Methyclothiazide?

The CAS number of Methyclothiazide is 135-07-9.

What are the molecular formula and molecular weight of Methyclothiazide?

Methyclothiazide has molecular formula C9H11Cl2N3O4S2 and molecular weight 360.237 g/mol.

What are the upstream and downstream products of Methyclothiazide?

For Methyclothiazide, Upstream Products: 4-Amino-6-chlorobenzene-1,3-disulfonamide, Chloroacetaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Methyclothiazide (CAS 135-07-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959225-3 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.