GSK343
1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺
Also known as: 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide, 1-Isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide, GSK 343, GSK-343, GSK-343/GSK343, 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-, N-((2-hydroxy-6-methyl-4-propylpyridin-3-yl)methyl)-1-isopropyl-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide
GSK343 (CAS 1346704-33-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C31H39N7O2 and a molecular weight of 541.687 g/mol. It is also known as 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide, 1-Isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide and GSK 343. Key properties include a boiling point of 797.4±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 436.0±32.9 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1346704-33-3
- Jingsj CID
- J-1956582-6
- Molecular Formula
- C31H39N7O2
- Chinese Name
- 1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺
- Molecular Weight
- 541.687 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 797.4±60.0 °C at 760 mmHg |
|---|---|
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 436.0±32.9 °C |
| Exact Mass | 541.316528 |
| PSA | 99.41000 |
| LogP | 3.22 |
| Appearance | , white to beige to brown |
| Vapor Pressure | 0.0±2.8 mmHg at 25°C |
| Refractive Index | 1.654 |
| Storage Conditions | 2-8°C |
| Additional Property | DMSO: soluble15mg/mL, clear |
GHS Safety & Compliance
- H302 — Harmful if swallowed
Activity & Biological Data
| Target | IC50: 4 nM (EZH2), 240 nM (EZH1)[1] |
|---|---|
| Additional Information | [1]. Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. [2]. Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42(5):458-64. |
Frequently Asked Questions
What is the CAS number of GSK343?
The CAS number of GSK343 is 1346704-33-3.
What are the molecular formula and molecular weight of GSK343?
GSK343 has molecular formula C31H39N7O2 and molecular weight 541.687 g/mol.
Is GSK343 hazardous?
GSK343 has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "GSK343 (CAS 1346704-33-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956582-6 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.