Tolcapone
托卡朋
Also known as: Ro 40-7592, Tasmar, 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone, (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone, 1-(3,4-Dihydroxy-5-nitrophenyl)-1-(4-methylphenyl)methanone
Tolcapone (CAS 134308-13-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H11NO5 and a molecular weight of 273.241 g/mol. It is also known as Ro 40-7592, Tasmar and 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone. Key properties include a melting point of 126-128ºC, a boiling point of 485.6±45.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 205.7±17.2 °C. It is classified under GHS with signal word Warning and hazard statements H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 134308-13-7
- Jingsj CID
- J-1958004-7
- Molecular Formula
- C14H11NO5
- Chinese Name
- 托卡朋
- Molecular Weight
- 273.241 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 126-128ºC |
|---|---|
| Boiling Point | 485.6±45.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 205.7±17.2 °C |
| Exact Mass | 273.063721 |
| PSA | 103.35000 |
| LogP | 4.07 |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
| Refractive Index | 1.661 |
| Storage Conditions | -20°C Freezer |
GHS Safety & Compliance
- H400 — Very toxic to aquatic life
Activity & Biological Data
| Additional Information | [1]. Neil E. Paterson, Jennifer Ricciardi, Caitlin Wetzler, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neuros [2]. Saviana Di Giovanni, Simona Eleuteri, Katerina E. Paleologou, et al. Entacapone and Tolcapone, Two Catechol O-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity. The Journal of Bi [3]. Panos Bitsios, Panos Roussos1. Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia. Pharmacogenomics. 2001,12 (4): 559-566. [4]. M.A. Vieira-Coelho, P. Soares-da-Silva. Ontogenic aspects of liver and kidney catechol-O- methyltransferase sensitivity to tolcapone. British Journal of Pharmacology.1996,117 (3):516-520. [5]. J. Dingemanse, K. Jorga, G. Zurcher,et al. Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa. British Journal of Clinical Pharmacology 1995, 40 (3):253-262. |
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Frequently Asked Questions
What is the CAS number of Tolcapone?
The CAS number of Tolcapone is 134308-13-7.
What are the molecular formula and molecular weight of Tolcapone?
Tolcapone has molecular formula C14H11NO5 and molecular weight 273.241 g/mol.
Is Tolcapone hazardous?
Tolcapone has GHS signal word Warning and hazard statements H400 — Very toxic to aquatic life.
What are the upstream and downstream products of Tolcapone?
For Tolcapone, Upstream Products: 3-O-Methyltolcapone.
Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Tolcapone (CAS 134308-13-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958004-7 (accessed 2026-10-28).
Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.