Tyrphostin B42 (AG-490)

Also known as: (2E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide, 2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE, 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E)-, AG 490, AG 490 - CAS 133550-30-8 - Calbiochem, AG-490, AG-490 (TYRPHOSTIN B42), AG490, CS-316, MFCD00209833, N-BENZYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE, N-BENZYL-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE, N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, TYROPHOSTIN AG490, TYRPHOSTIN AG 490, Tyrphostin AG 490, Tyrphostin B42, ZINC02557947

Tyrphostin B42 (AG-490) (CAS 133550-30-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H14N2O3 and a molecular weight of 294.305 g/mol. It is also known as (2E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide and (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide. Key properties include a melting point of 215°C(lit.), a boiling point of 615.2±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 325.9±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 133550-30-8
Jingsj CID: J-28111-3
Molecular Formula: C₁₇H₁₄N₂O₃
Molecular Weight: 294.305 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	215°C(lit.)
Boiling Point	615.2±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	325.9±31.5 °C
Exact Mass	294.100433
PSA	93.35000
LogP	2.11
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.679
Additional Property	ethanol: 5 mg/mL

GHS Safety & Compliance

Acute Toxicity / Environmental HazardSignal word: Danger

H301 — Toxic if swallowed
H400 — Very toxic to aquatic life

Activity & Biological Data

Target	EGFR Stat-3
Additional Information	[1]. Dowlati A, et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr;3(4):459-63 [2]. Wang LH, et al. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1;162(7):3897-904. [3]. Davoodi-Semiromi A, et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One. 2012;7(5):e36079. [4]. Cheppudira BP, et al. Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. Biomed Rep. 2015 Sep;3(5):703-706.

Target

EGFR Stat-3

Additional Information

[1]. Dowlati A, et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr;3(4):459-63 [2]. Wang LH, et al. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1;162(7):3897-904. [3]. Davoodi-Semiromi A, et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One. 2012;7(5):e36079. [4]. Cheppudira BP, et al. Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. Biomed Rep. 2015 Sep;3(5):703-706.

Customs & Trade Information

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Tyrphostin B42 (AG-490)?

The CAS number of Tyrphostin B42 (AG-490) is 133550-30-8.

What are the molecular formula and molecular weight of Tyrphostin B42 (AG-490)?

Tyrphostin B42 (AG-490) has molecular formula C17H14N2O3 and molecular weight 294.305 g/mol.

Is Tyrphostin B42 (AG-490) hazardous?

Tyrphostin B42 (AG-490) has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H400 — Very toxic to aquatic life.

What are the upstream and downstream products of Tyrphostin B42 (AG-490)?

For Tyrphostin B42 (AG-490), Upstream Products: N-Benzyl-2-cyanoacetamide, 3,4-Dihydroxybenzaldehyde, Benzylamine.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tyrphostin B42 (AG-490) (CAS 133550-30-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28111-3 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.