Lactacystin

乳胞素

Also known as: (+)-Lactacystin, Lactacystin (Native), Lactacystin, synthetic, Lactacystin, Streptomyces sp, N-Acetyl-S-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinyl]carbonyl]-L-cysteine, N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine, 3S-Hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine, Aids008388, MFCD01076525

Lactacystin (CAS 133343-34-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H24N2O7S and a molecular weight of 376.425 g/mol. It is also known as (+)-Lactacystin, Lactacystin (Native) and Lactacystin, synthetic. Key properties include a melting point of 233-235ºC dec., a boiling point of 714.9±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 386.1±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 133343-34-7
Jingsj CID: J-12124-0
Molecular Formula: C₁₅H₂₄N₂O₇S
Chinese Name: 乳胞素
Molecular Weight: 376.425 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	233-235ºC dec.
Boiling Point	714.9±60.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	386.1±32.9 °C
Exact Mass	376.130432
PSA	178.33000
LogP	-1.10
Vapor Pressure	0.0±5.2 mmHg at 25°C
Refractive Index	1.560

Activity & Biological Data

Target	IC50: 4.8 μM (proteasome)[1]
Additional Information	[1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67. [2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.

Target

IC50: 4.8 μM (proteasome)[1]

Additional Information

[1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67. [2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.

Frequently Asked Questions

What is the CAS number of Lactacystin?

The CAS number of Lactacystin is 133343-34-7.

What are the molecular formula and molecular weight of Lactacystin?

Lactacystin has molecular formula C15H24N2O7S and molecular weight 376.425 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Lactacystin (CAS 133343-34-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-12124-0 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.