Trichlormethiazide

Also known as: 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide, Trichloromethiazide, Naqua, Metahydrin, Fluitran

Trichlormethiazide (CAS 133-67-5) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C8H8Cl3N3O4S2 and a molecular weight of 380.656 g/mol. Key properties include a melting point of 248-250ºC, a boiling point of 631.3±65.0 °C at 760 mmHg, a density of 1.7±0.1 g/cm3 and a flash point of 335.6±34.3 °C. It is classified under GHS with signal word Danger and hazard statements H317 — May cause an allergic skin reaction and H334 — May cause allergy or asthma symptoms if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 133-67-5
Jingsj CID: J-43549-5
Molecular Formula: C₈H₈Cl₃N₃O₄S₂
Molecular Weight: 380.656 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	248-250ºC
Boiling Point	631.3±65.0 °C at 760 mmHg
Density	1.7±0.1 g/cm3
Flash Point	335.6±34.3 °C
Exact Mass	378.902191
PSA	135.12000
LogP	0.24
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.625

GHS Safety & Compliance

Health HazardSignal word: Danger

H317 — May cause an allergic skin reaction
H334 — May cause allergy or asthma symptoms if inhaled

Activity & Biological Data

Additional Information	[1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24. [2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63. [3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7.

Additional Information

[1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24. [2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63. [3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7.

Customs & Trade Information

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of Trichlormethiazide?

The CAS number of Trichlormethiazide is 133-67-5.

What are the molecular formula and molecular weight of Trichlormethiazide?

Trichlormethiazide has molecular formula C8H8Cl3N3O4S2 and molecular weight 380.656 g/mol.

Is Trichlormethiazide hazardous?

Trichlormethiazide has GHS signal word Danger and hazard statements H317 — May cause an allergic skin reaction; H334 — May cause allergy or asthma symptoms if inhaled.

What are the upstream and downstream products of Trichlormethiazide?

For Trichlormethiazide, Upstream Products: 4-Amino-6-chlorobenzene-1,3-disulfonamide, Dichloroacetaldehyde diethyl acetal; Downstream Products: 4-Amino-6-chlorobenzene-1,3-disulfonamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Trichlormethiazide (CAS 133-67-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-43549-5 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.