Senecionine

千里光宁

Also known as: Aureine, Sencionine, SENECIONIN, 12-Hydroxysenecionan-11,16-dione, (15cis)-12-Hydroxysenecionan-11,16-dione, (3Z,5R,6R,14aR,14bR)-3-Ethylidene-6-hydroxy-5,6-dimethyl-3,4,5,6,9,11,13,14,14a,14b-decahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, (15Z)-12-Hydroxysenecionan-11,16-dione, MFCD00221720

Senecionine (CAS 130-01-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H25NO5 and a molecular weight of 335.395 g/mol. It is also known as Aureine, Sencionine and SENECIONIN. Key properties include a melting point of 236ºC(lit.), a boiling point of 563.7±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 294.7±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 130-01-8
Jingsj CID: J-34237-9
Molecular Formula: C₁₈H₂₅NO₅
Chinese Name: 千里光宁
Molecular Weight: 335.395 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	236ºC(lit.)
Boiling Point	563.7±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	294.7±30.1 °C
Exact Mass	335.173279
PSA	76.07000
LogP	0.88
Vapor Pressure	0.0±3.5 mmHg at 25°C
Refractive Index	1.570

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Additional Information	[1]. Wang C, et al. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem. 2011 Jul;401(1):275-87. [2]. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8. [3]. Tu ZB, et al. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J Pharm Sci. 1988 May;77(5):461-3.

Additional Information

[1]. Wang C, et al. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem. 2011 Jul;401(1):275-87. [2]. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8. [3]. Tu ZB, et al. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J Pharm Sci. 1988 May;77(5):461-3.

Frequently Asked Questions

What is the CAS number of Senecionine?

The CAS number of Senecionine is 130-01-8.

What are the molecular formula and molecular weight of Senecionine?

Senecionine has molecular formula C18H25NO5 and molecular weight 335.395 g/mol.

Is Senecionine hazardous?

Senecionine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Senecionine?

For Senecionine, Downstream Products: Senecionine N-oxide.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Senecionine (CAS 130-01-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-34237-9 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.