1,9-Pyrazoloanthrone

吡唑蒽酮

Also known as: SP600125, SP-600125, JNK Inhibitor II, Anthra[1,9-cd]pyrazol-6(2H)-one, Dibenzo[cd,g]indazol-6(2H)-one, Pyrazolanthrone, NSC 75890, C.I. 70300, 1,6-dihydrodibenzo[cd,g]indazol-6-one

1,9-Pyrazoloanthrone (CAS 129-56-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C14H8N2O and a molecular weight of 220.226 g/mol. It is also known as SP600125, SP-600125 and JNK Inhibitor II. Key properties include a melting point of 281~282℃, a boiling point of 489.3±14.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 246.8±26.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 129-56-6
Jingsj CID: J-1990805-2
Molecular Formula: C₁₄H₈N₂O
Chinese Name: 吡唑蒽酮
Molecular Weight: 220.226 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	281~282℃
Boiling Point	489.3±14.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	246.8±26.5 °C
Exact Mass	220.063660
PSA	45.75000
LogP	3.18
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.799
Additional Property	H2O: insoluble

Activity & Biological Data

Target	JNK1:40 nM (IC50) JNK2:40 nM (IC50) JNK3:90 nM (IC50) Autophagy
Additional Information	[1]. Bennett BL, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A, 2001, 98(24), 13681-13686. [2]. Vaishnav D, et al. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun, 2003, 307(4), 855-860. [3]. Kim JA, et al. SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition. Oncogene, 2010, 29(11), 1702-1716. [4]. Zheng Y, et al. JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation ofclaudin-4. Exp Ther Med. 2014 Jul;8(1):153-158. [5]. Zhang H, et al. SP600125 Suppresses Keap1 Expression and Results in NRF2-mediated Prevention of Diabetic Nephropathy. J Mol Endocrinol. J Mol Endocrinol. 2018 Feb;60(2):145-157.

Target

JNK1:40 nM (IC50) JNK2:40 nM (IC50) JNK3:90 nM (IC50) Autophagy

Additional Information

[1]. Bennett BL, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A, 2001, 98(24), 13681-13686. [2]. Vaishnav D, et al. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun, 2003, 307(4), 855-860. [3]. Kim JA, et al. SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition. Oncogene, 2010, 29(11), 1702-1716. [4]. Zheng Y, et al. JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation ofclaudin-4. Exp Ther Med. 2014 Jul;8(1):153-158. [5]. Zhang H, et al. SP600125 Suppresses Keap1 Expression and Results in NRF2-mediated Prevention of Diabetic Nephropathy. J Mol Endocrinol. J Mol Endocrinol. 2018 Feb;60(2):145-157.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 1,9-Pyrazoloanthrone?

The CAS number of 1,9-Pyrazoloanthrone is 129-56-6.

What are the molecular formula and molecular weight of 1,9-Pyrazoloanthrone?

1,9-Pyrazoloanthrone has molecular formula C14H8N2O and molecular weight 220.226 g/mol.

What are the upstream and downstream products of 1,9-Pyrazoloanthrone?

For 1,9-Pyrazoloanthrone, Upstream Products: 1-Chloroanthraquinone, 1-aminoanthraquinone.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "1,9-Pyrazoloanthrone (CAS 129-56-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1990805-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.