Primidone

Also known as: 2-Deoxyphenobarbital, 2-Desoxyphenobarbital, 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione, Mysoline, Primaclone, Sertan

Primidone (CAS 125-33-7) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C12H14N2O2 and a molecular weight of 218.25200 g/mol. Key properties include a melting point of 281-282°C, a boiling point of 520.7ºC at 760mmHg, a density of 1.138g/cm3 and a flash point of 228.2ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H351 — Suspected of causing cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 125-33-7
Jingsj CID: J-11425-3
Molecular Formula: C₁₂H₁₄N₂O₂
Molecular Weight: 218.25200 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	281-282°C
Boiling Point	520.7ºC at 760mmHg
Density	1.138g/cm3
Flash Point	228.2ºC
Exact Mass	218.10600
PSA	58.20000
LogP	1.19550
Vapor Pressure	6.08E-11mmHg at 25°C
Refractive Index	1.528
Additional Property	<0.1 g/100 mL at 19 ºC

GHS Safety & Compliance

Irritant / Health HazardSignal word: Warning

H302 — Harmful if swallowed
H351 — Suspected of causing cancer

Activity & Biological Data

Additional Information	[1]. Macdonald, R.L. and K.M. Kelly, Antiepileptic drug mechanisms of action. Epilepsia, 1995. 36 Suppl 2: p. S2-12. [2]. Calzetti, S., et al., Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry, 1981. 44(10): p. 932-4. [3]. Perucca, E., et al., A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol, 1984. 18(3): p. 401-10.

Additional Information

[1]. Macdonald, R.L. and K.M. Kelly, Antiepileptic drug mechanisms of action. Epilepsia, 1995. 36 Suppl 2: p. S2-12. [2]. Calzetti, S., et al., Phenylethylmalonamide in essential tremor. A double-blind controlled study. J Neurol Neurosurg Psychiatry, 1981. 44(10): p. 932-4. [3]. Perucca, E., et al., A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol, 1984. 18(3): p. 401-10.

Frequently Asked Questions

What is the CAS number of Primidone?

The CAS number of Primidone is 125-33-7.

What are the molecular formula and molecular weight of Primidone?

Primidone has molecular formula C12H14N2O2 and molecular weight 218.25200 g/mol.

Is Primidone hazardous?

Primidone has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H351 — Suspected of causing cancer.

What are the upstream and downstream products of Primidone?

For Primidone, Upstream Products: 5-ethyldihydro-5-phenyl-2-thioxopyrimidine-4,6(1H,5H)-dione, 2-Ethyl-2-phenylmalonamide, Methanimidic acid, (Z)-; Downstream Products: 2-Ethyl-2-phenylmalonamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Primidone (CAS 125-33-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-11425-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.