(R)-(+)-HA-966

R(+)-3-氨基-1-羟基-2-吡咯烷酮

Also known as: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one, MFCD00078583, R(+)-3-Amino-1-hydroxy-2-pyrrolidinone, (3R)-3-Amino-1-hydroxy-2-pyrrolidinone, (+)-HA-966, (R)-HA-966, Zinc03791818

(R)-(+)-HA-966 (CAS 123931-04-4) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C4H8N2O2 and a molecular weight of 116.11900 g/mol. It is also known as (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one, MFCD00078583 and R(+)-3-Amino-1-hydroxy-2-pyrrolidinone. Key properties include a boiling point of 258.6ºC at 760mmHg, a density of 1.436g/cm3 and a flash point of 110.2ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 123931-04-4
Jingsj CID: J-12266-7
Molecular Formula: C₄H₈N₂O₂
Chinese Name: R(+)-3-氨基-1-羟基-2-吡咯烷酮
Molecular Weight: 116.11900 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	258.6ºC at 760mmHg
Density	1.436g/cm3
Flash Point	110.2ºC
Exact Mass	116.05900
PSA	66.56000
Vapor Pressure	0.002mmHg at 25°C
Refractive Index	1.59

Activity & Biological Data

Target	glycine site of the NMDA receptor[1][2]
Additional Information	[1]. Hutson PH, et al. R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol. 1991 Aug;103(4):2037-44. [2]. Witkin JM, et al. Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275(3):1267-73. [3]. Christensen D, et al. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. Br J Pharmacol. 1998 Dec;125(8):1641-50.

Target

glycine site of the NMDA receptor[1][2]

Additional Information

[1]. Hutson PH, et al. R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol. 1991 Aug;103(4):2037-44. [2]. Witkin JM, et al. Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275(3):1267-73. [3]. Christensen D, et al. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. Br J Pharmacol. 1998 Dec;125(8):1641-50.

Frequently Asked Questions

What is the CAS number of (R)-(+)-HA-966?

The CAS number of (R)-(+)-HA-966 is 123931-04-4.

What are the molecular formula and molecular weight of (R)-(+)-HA-966?

(R)-(+)-HA-966 has molecular formula C4H8N2O2 and molecular weight 116.11900 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(R)-(+)-HA-966 (CAS 123931-04-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-12266-7 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.