Loxoribine

洛索立宾

Also known as: RWJ 21757, 7-Allyl-7,8-dihydro-8-oxoguanosine, 7-Allyl-8-oxoguanosine, 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine, 7,8-Dihydro-8-oxo-7-allyl-guanosine, Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-, 7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione, 7-allyl-8-oxo-G

Loxoribine (CAS 121288-39-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H17N5O6 and a molecular weight of 339.30400 g/mol. It is also known as RWJ 21757, 7-Allyl-7,8-dihydro-8-oxoguanosine and 7-Allyl-8-oxoguanosine. Key properties include a melting point of 227-230ºC(lit.), a boiling point of 591.8ºC at 760mmHg, a density of 1.92g/cm3 and a flash point of 311.7ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 121288-39-9
Jingsj CID: J-49757-2
Molecular Formula: C₁₃H₁₇N₅O₆
Chinese Name: 洛索立宾
Molecular Weight: 339.30400 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	227-230ºC(lit.)
Boiling Point	591.8ºC at 760mmHg
Density	1.92g/cm3
Flash Point	311.7ºC
Exact Mass	339.11800
PSA	168.62000
Vapor Pressure	1.81E-16mmHg at 25°C
Refractive Index	1.812

Activity & Biological Data

Target	TLR7[1]
Additional Information	[1]. Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97. [2]. Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33. [3]. Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82.

Target

TLR7[1]

Additional Information

[1]. Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97. [2]. Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33. [3]. Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82.

Frequently Asked Questions

What is the CAS number of Loxoribine?

The CAS number of Loxoribine is 121288-39-9.

What are the molecular formula and molecular weight of Loxoribine?

Loxoribine has molecular formula C13H17N5O6 and molecular weight 339.30400 g/mol.

What are the upstream and downstream products of Loxoribine?

For Loxoribine, Upstream Products: 8-Bromoguanosine, Allyl bromide.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Loxoribine (CAS 121288-39-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49757-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.