Alendronate sodium trihydrate

阿仑膦酸钠三水合物

Also known as: Alendronate monosodium trihydrate, Alendronic acid monosodium salt trihydrate, Sodium alendronate trihydrate, Monosodium alendronate trihydrate, Sodium hydrogen (4-amino-1-hydroxy-1-phosphonobutyl)phosphonate hydrate (1:1:3), Fosamax, Adronat, Fosamsx

Alendronate sodium trihydrate (CAS 121268-17-5) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C4H18NNaO10P2 and a molecular weight of 325.124 g/mol. It is also known as Alendronate monosodium trihydrate, Alendronic acid monosodium salt trihydrate and Sodium alendronate trihydrate. Key properties include a melting point of 245°C, a boiling point of 616.7ºC at 760 mmHg, a density of 1.857g/cm3 and a flash point of 326.7ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 121268-17-5
Jingsj CID: J-1114717-2
Molecular Formula: C₄H₁₈NNaO₁₀P₂
Chinese Name: 阿仑膦酸钠三水合物
Molecular Weight: 325.124 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	245°C
Boiling Point	616.7ºC at 760 mmHg
Density	1.857g/cm3
Flash Point	326.7ºC
Exact Mass	325.030365
PSA	211.45000
Storage Conditions	−20°C
Stability	Store in freezer
Additional Property	water, double-distilled: 10 mg/mL

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Target	IC50: 460 nM (farnesyl diphosphate synthase)
Additional Information	[1]. Fisher JE, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. [2]. Bergstrom JD, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. [3]. Keller RK, et al. Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. Biochem Biophys Res Commun. 1999 Dec 20;266(2):560-3. [4]. Elliott SN, et al. Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci. 1998;62(1):77-91. [5]. Stearns ME, et al. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion Metastasis. 1996;16(3):116-31.

Target

IC50: 460 nM (farnesyl diphosphate synthase)

Additional Information

[1]. Fisher JE, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. [2]. Bergstrom JD, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. [3]. Keller RK, et al. Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. Biochem Biophys Res Commun. 1999 Dec 20;266(2):560-3. [4]. Elliott SN, et al. Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci. 1998;62(1):77-91. [5]. Stearns ME, et al. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion Metastasis. 1996;16(3):116-31.

Frequently Asked Questions

What is the CAS number of Alendronate sodium trihydrate?

The CAS number of Alendronate sodium trihydrate is 121268-17-5.

What are the molecular formula and molecular weight of Alendronate sodium trihydrate?

Alendronate sodium trihydrate has molecular formula C4H18NNaO10P2 and molecular weight 325.124 g/mol.

Is Alendronate sodium trihydrate hazardous?

Alendronate sodium trihydrate has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Alendronate sodium trihydrate?

For Alendronate sodium trihydrate, Upstream Products: Alendronic acid, gamma-Aminobutyric acid, 2-Pyrrolidinone; Downstream Products: Alendronic acid.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Alendronate sodium trihydrate (CAS 121268-17-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1114717-2 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.