Mibefradil dihydrochloride

米贝拉地尔

Also known as: Ro 40-5967, Mibefradil hydrochloride, Mibefradil diHCl, Mibefradil (dihydrochloride), (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate dihydrochloride, MIBEFRADIL

Mibefradil dihydrochloride (CAS 116666-63-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C29H40Cl2FN3O3 and a molecular weight of 568.551 g/mol. It is also known as Ro 40-5967, Mibefradil hydrochloride and Mibefradil diHCl. Key properties include a boiling point of 647.6ºC at 760mmHg and a flash point of 345.5ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 116666-63-8
Jingsj CID: J-1971084-0
Molecular Formula: C₂₉H₄₀Cl₂FN₃O₃
Chinese Name: 米贝拉地尔
Molecular Weight: 568.551 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	647.6ºC at 760mmHg
Flash Point	345.5ºC
Exact Mass	567.243103
PSA	67.45000
LogP	6.87490
Vapor Pressure	1.17E-16mmHg at 25°C
Storage Conditions	2-8℃

Activity & Biological Data

Target	IC50: 2.7 μM (T-type calcium channel), 18.6 μM (L-type calcium channel)[1]
Additional Information	[1]. Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8. [2]. Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35. [3]. Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044. [4]. Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6.

Target

IC50: 2.7 μM (T-type calcium channel), 18.6 μM (L-type calcium channel)[1]

Additional Information

[1]. Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8. [2]. Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35. [3]. Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044. [4]. Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6.

Frequently Asked Questions

What is the CAS number of Mibefradil dihydrochloride?

The CAS number of Mibefradil dihydrochloride is 116666-63-8.

What are the molecular formula and molecular weight of Mibefradil dihydrochloride?

Mibefradil dihydrochloride has molecular formula C29H40Cl2FN3O3 and molecular weight 568.551 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Mibefradil dihydrochloride (CAS 116666-63-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971084-0 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.