Remacemide hydrochloride

盐酸瑞马酰胺

Also known as: 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide hydrochloride, 2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride, Remacemide HCl, FPL 12924AA, PR 934-423A, T23231

Remacemide hydrochloride (CAS 111686-79-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C17H21ClN2O and a molecular weight of 304.81400 g/mol. It is also known as 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide hydrochloride, 2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride and Remacemide HCl. Key properties include a boiling point of 466.4ºC at 760mmHg and a flash point of 235.9ºC. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed, H318 — Causes serious eye damage and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 111686-79-4
Jingsj CID: J-1958111-6
Molecular Formula: C₁₇H₂₁ClN₂O
Chinese Name: 盐酸瑞马酰胺
Molecular Weight: 304.81400 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	466.4ºC at 760mmHg
Flash Point	235.9ºC
Exact Mass	304.13400
PSA	55.12000
LogP	4.11260
Vapor Pressure	7.09E-09mmHg at 25°C

GHS Safety & Compliance

Corrosion / Irritant / Environmental HazardSignal word: Danger

H302 — Harmful if swallowed
H318 — Causes serious eye damage
H400 — Very toxic to aquatic life

Activity & Biological Data

Target	IC50: 68-76 μM (NMDA receptor)[1] IC50:160.6 μM(sodium channel)[2]
Additional Information	[1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [2]. Sarah Santangeli, et al. Na + channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59.

Target

IC50: 68-76 μM (NMDA receptor)[1] IC50:160.6 μM(sodium channel)[2]

Additional Information

[1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [2]. Sarah Santangeli, et al. Na + channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59.

Customs & Trade Information

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Remacemide hydrochloride?

The CAS number of Remacemide hydrochloride is 111686-79-4.

What are the molecular formula and molecular weight of Remacemide hydrochloride?

Remacemide hydrochloride has molecular formula C17H21ClN2O and molecular weight 304.81400 g/mol.

Is Remacemide hydrochloride hazardous?

Remacemide hydrochloride has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H318 — Causes serious eye damage; H400 — Very toxic to aquatic life.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Remacemide hydrochloride (CAS 111686-79-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958111-6 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.