Metformin hydrochloride

盐酸二甲双胍

Also known as: Metformin HCl, 1,1-Dimethylbiguanide hydrochloride, N1,N1-Dimethylbiguanide hydrochloride, 3-(Diaminomethylidene)-1,1-dimethylguanidine hydrochloride, Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1), Dimethylbiguanide hydrochloride, Glucophage, N,N-Dimethylimidodicarbonimidic diamide hydrochloride (1:1)

Metformin hydrochloride (CAS 1115-70-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C4H12ClN5 and a molecular weight of 165.625 g/mol. It is also known as Metformin HCl, 1,1-Dimethylbiguanide hydrochloride and N1,N1-Dimethylbiguanide hydrochloride. Key properties include a melting point of 223-226 °C(lit.), a boiling point of 224.1ºC at 760 mmHg and a flash point of 89.3ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1115-70-4
Jingsj CID: J-47603-0
Molecular Formula: C₄H₁₂ClN₅
Chinese Name: 盐酸二甲双胍
Molecular Weight: 165.625 g/mol
Category: Organic Acids
Last updated: 8/21/2026

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	223-226 °C(lit.)
Boiling Point	224.1ºC at 760 mmHg
Flash Point	89.3ºC
Exact Mass	165.078125
PSA	88.99000
LogP	1.05850
Vapor Pressure	0.0929mmHg at 25°C

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H315 — Causes skin irritation
H319 — Causes serious eye irritation

Activity & Biological Data

Target	AMPK Autophagy Mitophagy
Additional Information	[1]. Soraya H, et al. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84. [2]. Quaile MP, et al. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):340-7. [3]. Xue J, et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406. [4]. Otto M, et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94. [5]. Avci CB, et al. Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells. Asian Pac J Cancer Prev. 2013;14(2):765-8. [6]. Nie L, et al. The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics. 2017 Jul;16(7):1324-1334. [7]. Zhang D, et al. Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation. J Cell Mol Med. 2017 Jul 12.

Target

AMPK Autophagy Mitophagy

Additional Information

[1]. Soraya H, et al. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84. [2]. Quaile MP, et al. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):340-7. [3]. Xue J, et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406. [4]. Otto M, et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94. [5]. Avci CB, et al. Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells. Asian Pac J Cancer Prev. 2013;14(2):765-8. [6]. Nie L, et al. The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics. 2017 Jul;16(7):1324-1334. [7]. Zhang D, et al. Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation. J Cell Mol Med. 2017 Jul 12.

Customs & Trade Information

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Metformin hydrochloride?

The CAS number of Metformin hydrochloride is 1115-70-4.

What are the molecular formula and molecular weight of Metformin hydrochloride?

Metformin hydrochloride has molecular formula C4H12ClN5 and molecular weight 165.625 g/mol.

Is Metformin hydrochloride hazardous?

Metformin hydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Metformin hydrochloride?

For Metformin hydrochloride, Upstream Products: Metformin, Dimethylamine hydrochloride, Dimethylamine; Downstream Products: 6-(chloromethyl)-N,N-dimethyl-1,3,5-triazine-2,4-diamine, Metformin.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Metformin hydrochloride (CAS 1115-70-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-47603-0 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.