LDN-193189

Also known as: 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, DM-3189, LDN193189, 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

LDN-193189 (CAS 1062368-24-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C25H22N6 and a molecular weight of 406.482 g/mol. It is also known as 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, DM-3189 and LDN193189. Key property: a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1062368-24-4
Jingsj CID: J-1975328-5
Molecular Formula: C₂₅H₂₂N₆
Molecular Weight: 406.482 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.3±0.1 g/cm3
Exact Mass	406.190582
PSA	58.35000
LogP	1.81
Appearance	yellow to orange
Refractive Index	1.740
Storage Conditions	?20°C
Additional Property	H2O: soluble5mg/mL, clear (warmed)

Activity & Biological Data

Target	IC50: 5 nM (ALK2), 30 nM (ALK3)[1]
Additional Information	[1]. Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14(12), 1363-1369. [2]. Lee YC, et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res, 2011, 71(15), 5194-5203. [3]. Yang L, et al. Sildenefil increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4674-84.

Target

IC50: 5 nM (ALK2), 30 nM (ALK3)[1]

Additional Information

[1]. Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14(12), 1363-1369. [2]. Lee YC, et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res, 2011, 71(15), 5194-5203. [3]. Yang L, et al. Sildenefil increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4674-84.

Frequently Asked Questions

What is the CAS number of LDN-193189?

The CAS number of LDN-193189 is 1062368-24-4.

What are the molecular formula and molecular weight of LDN-193189?

LDN-193189 has molecular formula C25H22N6 and molecular weight 406.482 g/mol.

Data compiled from public chemical databases and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "LDN-193189 (CAS 1062368-24-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975328-5 (accessed 2026-10-28).

Data for reference only; verify specifications, grades and regulatory status with suppliers before purchase.