Fasudil hydrochloride

Also known as: Fasudil HCl, HA-1077, AT-877, Fasudil monohydrochloride, 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride, 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline hydrochloride, Eril, MFCD00943198

Fasudil hydrochloride (CAS 105628-07-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C14H18ClN3O2S and a molecular weight of 327.83700 g/mol. Key properties include a melting point of 222 °C(dec.), a boiling point of 506.2ºC at 760 mmHg and a flash point of 259.9ºC. It is listed by 1 supplier, from 67.20 to 100.00 CNY. Record last updated Nov 4, 2026.

CAS No.: 105628-07-7
Jingsj CID: J-1981263-0
Molecular Formula: C₁₄H₁₈ClN₃O₂S
Molecular Weight: 327.83700 g/mol
Category: Organic Acids
Last updated: 11/4/2026

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Supplier	Purity / Pack	Base Price	Unit Price	Origin
Maikuo Made to Order	98% 25g	¥1,680.00	$10.06 /gBest ¥67.20/g CNY	CN China MOQ 25g	View Product
Maikuo Made to Order	98% 5g	¥420.00	$12.57 /g ¥84.00/g CNY	CN China MOQ 5g	View Product
Maikuo Made to Order	98% 1g	¥100.00	$14.96 /g ¥100.00/g CNY	CN China MOQ 1g	View Product

Physicochemical Properties

Melting Point	222 °C(dec.)
Boiling Point	506.2ºC at 760 mmHg
Flash Point	259.9ºC
PSA	70.68000
LogP	4.17030
Additional Property	H2O: >200 mg/mL
SMILES	C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
InChIKey	LFVPBERIVUNMGV-UHFFFAOYSA-N
InChI	1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

Activity & Biological Data

Target	p160ROCK:0.33 μM (Ki) PKA:1 μM (Ki) PKC:9.3 μM (Ki) MLCK:55 μM (Ki)
Additional Information	[1]. Ono-Saito N, et al. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther. 1999 May-Jun;82(2-3):123-31. [2]. Asano T, et al. Mechanism of action of a novel antivasospasm drug, HA1077. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40. [3]. Asano T, et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 1989 Dec;98(4):1091-100. [4]. Negoro N, et al. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):211-5. [5]. Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. [6]. Zhang J, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80. [7]. Sun X, et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34 [8]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4.

Target

p160ROCK:0.33 μM (Ki) PKA:1 μM (Ki) PKC:9.3 μM (Ki) MLCK:55 μM (Ki)

Additional Information

[1]. Ono-Saito N, et al. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther. 1999 May-Jun;82(2-3):123-31. [2]. Asano T, et al. Mechanism of action of a novel antivasospasm drug, HA1077. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40. [3]. Asano T, et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 1989 Dec;98(4):1091-100. [4]. Negoro N, et al. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):211-5. [5]. Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. [6]. Zhang J, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80. [7]. Sun X, et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34 [8]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Fasudil hydrochloride?

The CAS number of Fasudil hydrochloride is 105628-07-7.

What are the molecular formula and molecular weight of Fasudil hydrochloride?

Fasudil hydrochloride has molecular formula C14H18ClN3O2S and molecular weight 327.83700 g/mol.

Which suppliers offer Fasudil hydrochloride?

1 supplier(s) listed; reference unit price ¥67.20–100.00 /g.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/4/2026

How to cite: Jingsj. "Fasudil hydrochloride (CAS 105628-07-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981263-0 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.