trans-4-Aminocrotonic acid

Also known as: (E)-4-aminobut-2-enoic acid, 4-amino-trans-crotonic acid, 4-amino-2-butenoic acid, TACA

trans-4-Aminocrotonic acid (CAS 38090-53-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C4H7NO2 and a molecular weight of 101.10400 g/mol. Key properties include a melting point of >158°C (lit.), a boiling point of 300.4ºC at 760 mmHg, a density of 1.169 g/cm3 and a flash point of 135.5ºC. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 38090-53-8
Jingsj CID: J-968514-7
Molecular Formula: C₄H₇NO₂
Molecular Weight: 101.10400 g/mol
Category: Organic Acids
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	>158°C (lit.)
Boiling Point	300.4ºC at 760 mmHg
Density	1.169 g/cm3
Flash Point	135.5ºC
Exact Mass	101.04800
PSA	63.32000
LogP	0.28620

Activity & Biological Data

Target	KD: 0.6 μM (GABAC)[1].
Additional Information	[1]. Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122(8):1551-1560. [2]. Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82(3):1489-1496. [3]. Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24(1):157-160.

Target

KD: 0.6 μM (GABAC)[1].

Additional Information

[1]. Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122(8):1551-1560. [2]. Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82(3):1489-1496. [3]. Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24(1):157-160.

Frequently Asked Questions

What is the CAS number of trans-4-Aminocrotonic acid?

The CAS number of trans-4-Aminocrotonic acid is 38090-53-8.

What are the molecular formula and molecular weight of trans-4-Aminocrotonic acid?

trans-4-Aminocrotonic acid has molecular formula C4H7NO2 and molecular weight 101.10400 g/mol.

What are the upstream and downstream products of trans-4-Aminocrotonic acid?

For trans-4-Aminocrotonic acid, Upstream Products: DL-4-Amino-3-hydroxybutanoic acid, 4-Bromocrotonic acid, Crotonic acid; Downstream Products: gamma-Aminobutyric acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "trans-4-Aminocrotonic acid (CAS 38090-53-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-968514-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.