(R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(R,E)-N-(4-((3-氯-4-氟苯基)氨基)-7-((四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基)丁-2-烯酰胺

Also known as: Afatinib Enantiomer, Afatinib Impurity 3, R-afatinib, (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3R)-tetrahydro-3-furanyloxy]-6-quinazolinyl}-4-(dimethylamino)-2-butenamide, (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide, 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, Afatinib-2

(R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (CAS 945553-91-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C24H25ClFN5O3 and a molecular weight of 485.938 g/mol. It is also known as Afatinib Enantiomer, Afatinib Impurity 3 and R-afatinib. Key properties include a boiling point of 676.9±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 363.2±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.

945553-91-3

Jingsj CID

J-967891-0

Molecular Formula

C₂₄H₂₅ClFN₅O₃

Chinese Name

(R,E)-N-(4-((3-氯-4-氟苯基)氨基)-7-((四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基)丁-2-烯酰胺

Molecular Weight

485.938 g/mol

Category

Pharma Intermediates

Last updated

8/21/2026