Deguelin

Also known as: (-)-Deguelin, (7aS,13aS)-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one, (7aS,13aS)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one, MFCD01740600

Deguelin (CAS 522-17-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C23H22O6 and a molecular weight of 394.417 g/mol. Key properties include a melting point of 85-87ºC(lit.), a boiling point of 560.1±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 244.7±30.2 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 522-17-8
Jingsj CID: J-90136-9
Molecular Formula: C₂₃H₂₂O₆
Molecular Weight: 394.417 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	85-87ºC(lit.)
Boiling Point	560.1±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	244.7±30.2 °C
Exact Mass	394.141632
PSA	63.22000
LogP	5.03
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.584

Activity & Biological Data

Target	Akt
Additional Information	[1]. Mehta R, et al. Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells. PLoS One. 2013 Jun 10;8(6):e65113. [2]. Yang YL, et al. Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells. PLoS One. 2013;8(1):e54736. [3]. Li Z, et al. Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis. Oncol Lett. 2012 Oct;4(4):677-681. [4]. Kang HW, et al. Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Dig Dis Sci. 2012 Nov;57(11):2873-82.

Target

Akt

Additional Information

[1]. Mehta R, et al. Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells. PLoS One. 2013 Jun 10;8(6):e65113. [2]. Yang YL, et al. Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells. PLoS One. 2013;8(1):e54736. [3]. Li Z, et al. Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis. Oncol Lett. 2012 Oct;4(4):677-681. [4]. Kang HW, et al. Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Dig Dis Sci. 2012 Nov;57(11):2873-82.

Frequently Asked Questions

What is the CAS number of Deguelin?

The CAS number of Deguelin is 522-17-8.

What are the molecular formula and molecular weight of Deguelin?

Deguelin has molecular formula C23H22O6 and molecular weight 394.417 g/mol.

What are the upstream and downstream products of Deguelin?

For Deguelin, Upstream Products: Tephrosin, Rotenone, Diazomethane; Downstream Products: Dehydrodeguelin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Deguelin (CAS 522-17-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-90136-9 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.