Foretinib

Also known as: GSK1363089, XL880, EXEL-2880, GSK089, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Foretinib (CAS 849217-64-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C34H34F2N4O6 and a molecular weight of 632.654 g/mol. Key properties include a boiling point of 828.5±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 454.8±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 849217-64-7
Jingsj CID: J-90002-7
Molecular Formula: C₃₄H₃₄F₂N₄O₆
Molecular Weight: 632.654 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	828.5±65.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	454.8±34.3 °C
Exact Mass	632.244629
PSA	116.45000
LogP	5.12
Vapor Pressure	0.0±3.0 mmHg at 25°C
Refractive Index	1.649
Storage Conditions	-20°C

Activity & Biological Data

Target	KDR:0.9 nM (IC50) c-Met:0.4 nM (IC50)
Additional Information	[1]. Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res, 2009, 69(20), 8009-8016. [2]. Kataoka Y, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs, 2011. [3]. Eder JP, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res, 2010, 16(13), 3507-3516.

Target

KDR:0.9 nM (IC50) c-Met:0.4 nM (IC50)

Additional Information

[1]. Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res, 2009, 69(20), 8009-8016. [2]. Kataoka Y, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs, 2011. [3]. Eder JP, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res, 2010, 16(13), 3507-3516.

Frequently Asked Questions

What is the CAS number of Foretinib?

The CAS number of Foretinib is 849217-64-7.

What are the molecular formula and molecular weight of Foretinib?

Foretinib has molecular formula C34H34F2N4O6 and molecular weight 632.654 g/mol.

What are the upstream and downstream products of Foretinib?

For Foretinib, Upstream Products: 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid, 4-(3-Chloropropyl)morpholine hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Foretinib (CAS 849217-64-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-90002-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.