Selisistat (EX 527)

Also known as: (S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE, 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE, >95%, 6-Chlor-1,2,3,4-tetrahydrocarbazol-1-carboxamid, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide EX-527 Selisistat, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide,racemic, 6-chloro-1,2,3,4,9-pentahydro-4aH-carbazolecarboxamide, 6-chloro-2,3,4,9-tetrahydro-1-H-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid amide, EX 527, EX 527 (SEN0014196), EX 527, >=98%, SEN0014196, SIRT1 Inhibitor III, UNII:L19ECD5014

Selisistat (EX 527) (CAS 49843-98-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H13ClN2O and a molecular weight of 248.708 g/mol. Key properties include a melting point of 179.0 to 183.0 °C, a boiling point of 531.7±38.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 275.4±26.8 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 49843-98-3
Jingsj CID: J-89946-7
Molecular Formula: C₁₃H₁₃ClN₂O
Molecular Weight: 248.708 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	179.0 to 183.0 °C
Boiling Point	531.7±38.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	275.4±26.8 °C
Exact Mass	248.071640
PSA	58.88000
LogP	2.22
Appearance	white to beige
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.688
Storage Conditions	Store at +4°C
Additional Property	Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide.

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H319 — Causes serious eye irritation

Activity & Biological Data

Target	SIRT1:98 nM (IC50) SIRT2:19.6 μM (IC50) SIRT3:48.7 μM (IC50)
Additional Information	[1]. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. [2]. Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. [3]. Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. [4]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

Target

SIRT1:98 nM (IC50) SIRT2:19.6 μM (IC50) SIRT3:48.7 μM (IC50)

Additional Information

[1]. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. [2]. Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. [3]. Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. [4]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

Frequently Asked Questions

What is the CAS number of Selisistat (EX 527)?

The CAS number of Selisistat (EX 527) is 49843-98-3.

What are the molecular formula and molecular weight of Selisistat (EX 527)?

Selisistat (EX 527) has molecular formula C13H13ClN2O and molecular weight 248.708 g/mol.

Is Selisistat (EX 527) hazardous?

Selisistat (EX 527) has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Selisistat (EX 527)?

For Selisistat (EX 527), Upstream Products: ethyl 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate, Ethyl 2-oxocyclohexanecarboxylate, ethyl 3-bromo-2-oxocyclohexanecarboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Selisistat (EX 527) (CAS 49843-98-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-89946-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.