Geissoschizine methyl ether

Also known as: geissoschizine methylether, Methyl (16Z,19E)-16-(methoxymethylene)coryn-19-en-17-oate, (Z)-methyl 2-((2S,12bS,E)-3-ethylidene-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate, Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αZ,2S,3E,12bS)-, geissoschizine methylether USP/EP/BP, methyl (Z)-2-[(2S,3E,12bS)-3-ethylidene-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

Geissoschizine methyl ether (CAS 60314-89-8) is a compound in the Ethers category listed in the Jingsj chemical database. It has the molecular formula C22H26N2O3 and a molecular weight of 366.45300 g/mol. Key property: a density of 1.2±0.1 g/cm3, 计算值. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 60314-89-8
Jingsj CID: J-898654-0
Molecular Formula: C₂₂H₂₆N₂O₃
Molecular Weight: 366.45300 g/mol
Category: Ethers
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.2±0.1 g/cm3, 计算值
Exact Mass	366.19400
PSA	54.56000
LogP	3.67450

Activity & Biological Data

Target	5-HT1A[2]
Additional Information	[1]. Matsumoto T, et al. In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan. Xenobiotica. 2016;46(4):325-34. [2]. Nishi A, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012 Apr 5;207:124-36.

Target

5-HT1A[2]

Additional Information

[1]. Matsumoto T, et al. In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan. Xenobiotica. 2016;46(4):325-34. [2]. Nishi A, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012 Apr 5;207:124-36.

Frequently Asked Questions

What is the CAS number of Geissoschizine methyl ether?

The CAS number of Geissoschizine methyl ether is 60314-89-8.

What are the molecular formula and molecular weight of Geissoschizine methyl ether?

Geissoschizine methyl ether has molecular formula C22H26N2O3 and molecular weight 366.45300 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Geissoschizine methyl ether (CAS 60314-89-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-898654-0 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.