Bisindolylmaleimide I (GF109203X)

Also known as: 1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrolyl-2,5-dione, 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione, 3-{1-[3-(Dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione, BIM-1, BISINDOLYLMALEIMIDE, Bisindolylmaleimide I (GF 109203X), GF 109203X, GF-109203X HCL, GF109203X HYDROCHLORIDE, GO 6850, GO 6850 HCL, InSolution? Bisindolylmaleimide I, MFCD00236428, RBT205 INHIBITOR, bisindolylmaleimide i

Bisindolylmaleimide I (GF109203X) (CAS 133052-90-1) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C25H24N4O2 and a molecular weight of 412.484 g/mol. Key properties include a melting point of 208-210ºC, a boiling point of 685.6±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 368.5±31.5 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H351 — Suspected of causing cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 133052-90-1
Jingsj CID: J-89800-0
Molecular Formula: C₂₅H₂₄N₄O₂
Molecular Weight: 412.484 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	208-210ºC
Boiling Point	685.6±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	368.5±31.5 °C
Exact Mass	412.189911
PSA	70.13000
LogP	3.88
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.687
Additional Property	DMSO: ~1 mg/mlsoluble \| Insoluble in water.

GHS Safety & Compliance

Irritant / Health HazardSignal word: Warning

H302 — Harmful if swallowed
H351 — Suspected of causing cancer

Activity & Biological Data

Target	Bovine brain PKC:10 nM (IC50) PKCβII:16 nM (IC50) PKCβI:17 nM (IC50) PKCα:20 nM (IC50) PKCγ:20 nM (IC50) FDGFR:65 μM (IC50)
Additional Information	[1]. Toullec D, et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991 Aug 25;266(24):15771-81. [2]. Vetri F, et al. Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor. Brain Res. 2017 Jan 15;1655:48-54.

Frequently Asked Questions

What is the CAS number of Bisindolylmaleimide I (GF109203X)?

The CAS number of Bisindolylmaleimide I (GF109203X) is 133052-90-1.

What are the molecular formula and molecular weight of Bisindolylmaleimide I (GF109203X)?

Bisindolylmaleimide I (GF109203X) has molecular formula C25H24N4O2 and molecular weight 412.484 g/mol.

Is Bisindolylmaleimide I (GF109203X) hazardous?

Bisindolylmaleimide I (GF109203X) has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H351 — Suspected of causing cancer.

What are the upstream and downstream products of Bisindolylmaleimide I (GF109203X)?

For Bisindolylmaleimide I (GF109203X), Upstream Products: Dimethylamine, Methyl indolyl-3-glyoxylate, Indole.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Bisindolylmaleimide I (GF109203X) (CAS 133052-90-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-89800-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.