Zapnometinib

Also known as: 2,8-dimercapto-6-hydroxypurine hydrate,1gr, 2-(2-chloro-4-iodoanilino)-3, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, ATR-002, Benzoic acid, 2-[(2-chloro-4-iodophenyl)amino]-3,4-difluoro-, zapnometinib

Zapnometinib (CAS 303175-44-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H7ClF2INO2 and a molecular weight of 409.55 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 303175-44-2
Jingsj CID: J-89598-7
Molecular Formula: C₁₃H₇ClF₂INO₂
Molecular Weight: 409.55 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	408.91800
PSA	49.33000
LogP	4.73760

Activity & Biological Data

Target	MEK:5.7 nM (IC50)
Additional Information	[1]. Laure M, et, al. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Jun;178:104806. [2]. Hamza H, et, al. Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002. Front Microbiol. 2021 Feb 12;12:611958. [3]. Bruchhagen C, et, al. Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound. Sci Rep. 2018 Jun 14;8(1):9114.

Target

MEK:5.7 nM (IC50)

Additional Information

[1]. Laure M, et, al. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Jun;178:104806. [2]. Hamza H, et, al. Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002. Front Microbiol. 2021 Feb 12;12:611958. [3]. Bruchhagen C, et, al. Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound. Sci Rep. 2018 Jun 14;8(1):9114.

Frequently Asked Questions

What is the CAS number of Zapnometinib?

The CAS number of Zapnometinib is 303175-44-2.

What are the molecular formula and molecular weight of Zapnometinib?

Zapnometinib has molecular formula C13H7ClF2INO2 and molecular weight 409.55 g/mol.

What are the upstream and downstream products of Zapnometinib?

For Zapnometinib, Upstream Products: 2-Chloro-4-iodoaniline, 2,3,4-Trifluorobenzoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Zapnometinib (CAS 303175-44-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-89598-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.