Filgotinib

Also known as: GLPG0634, N-(5-(4-((1,1-Dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide, N-[5-[4-[(1,1-Dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, UNII-3XVL385Q0M, SYN1158, G146034

Filgotinib (CAS 1206161-97-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H23N5O3S and a molecular weight of 425.504 g/mol. Key property: a density of 1.5±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1206161-97-8
Jingsj CID: J-884651-3
Molecular Formula: C₂₁H₂₃N₅O₃S
Molecular Weight: 425.504 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.5±0.1 g/cm3
Exact Mass	425.152161
PSA	108.28000
LogP	0.79
Refractive Index	1.748
Storage Conditions	2-8°C

Activity & Biological Data

Target	JAK1:10 nM (IC50) JAK2:28 nM (IC50) Tyk2:116 nM (IC50) JAK3:810 nM (IC50)
Additional Information	[1]. Van Rompaey L, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013, 191(7), 3568-3577. [2]. Menet CJ, et al. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J Med Chem. 2014 Nov 17.

Frequently Asked Questions

What is the CAS number of Filgotinib?

The CAS number of Filgotinib is 1206161-97-8.

What are the molecular formula and molecular weight of Filgotinib?

Filgotinib has molecular formula C21H23N5O3S and molecular weight 425.504 g/mol.

What are the upstream and downstream products of Filgotinib?

For Filgotinib, Upstream Products: Thiomorpholine-1,1-dioxide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Filgotinib (CAS 1206161-97-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-884651-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.