Aloxistatin

Also known as: E-64d, EST, Loxistatin, Loxastatin, Estate, EP453, Ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate, L-trans-epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester, (2S,3S)-ethyl 3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester

Aloxistatin (CAS 88321-09-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H30N2O5 and a molecular weight of 342.431 g/mol. Key properties include a melting point of 126.2°C, a boiling point of 470.5±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 238.4±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 88321-09-9
Jingsj CID: J-8138-9
Molecular Formula: C₁₇H₃₀N₂O₅
Molecular Weight: 342.431 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	126.2°C
Boiling Point	470.5±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	238.4±31.5 °C
Exact Mass	342.215485
PSA	97.03000
LogP	3.64
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.530
Additional Property	Soluble in DMSO, DMF or ethanol

Activity & Biological Data

Target	Cysteine protease[1]
Additional Information	[1]. Doh-Ura K, et al. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol. 2000 May;74(10):4894-7. [2]. Konjar S, et al. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. [3]. Mullins SR, et al. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012 Dec;393(12):1405-16. [4]. Hook G, et al. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. J Alzheimers Dis. 2011;26(2):387-408. [5]. Cheng XW, et al. Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment. Am J Pathol. 2008 Aug;173(2):358-69.

Target

Cysteine protease[1]

Additional Information

[1]. Doh-Ura K, et al. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol. 2000 May;74(10):4894-7. [2]. Konjar S, et al. Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology. 2010 Oct;131(2):257-67. [3]. Mullins SR, et al. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012 Dec;393(12):1405-16. [4]. Hook G, et al. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. J Alzheimers Dis. 2011;26(2):387-408. [5]. Cheng XW, et al. Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment. Am J Pathol. 2008 Aug;173(2):358-69.

Frequently Asked Questions

What is the CAS number of Aloxistatin?

The CAS number of Aloxistatin is 88321-09-9.

What are the molecular formula and molecular weight of Aloxistatin?

Aloxistatin has molecular formula C17H30N2O5 and molecular weight 342.431 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Aloxistatin (CAS 88321-09-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-8138-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.