N-tert-Butyl-α-phenylnitrone

Also known as: N-tert-Butyl-alpha-phenylnitrone, PBN, Phenyl N-tert-butylnitrone, N-Benzylidene-tert-butylamine N-oxide, N-Benzylidene-tert-butylamine oxide, 2-Methyl-N-(phenylmethylene)-2-propanamine N-oxide, C-Phenyl-N-tert-butylnitrone, tert-Butyl(benzylidene)amine N-oxide, Alpha-Phenyl-N-tert-butylnitrone, N-tert-Butyl-2-phenylnitrone, N-tert-Butyl-C-phenylnitrone

N-tert-Butyl-α-phenylnitrone (CAS 3376-24-7) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C11H15NO and a molecular weight of 177.243 g/mol. Key properties include a melting point of 71-75ºC, a boiling point of 283.3±23.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 118.5±15.4 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 3376-24-7
Jingsj CID: J-7895-5
Molecular Formula: C₁₁H₁₅NO
Molecular Weight: 177.243 g/mol
Category: Ketones
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	71-75ºC
Boiling Point	283.3±23.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	118.5±15.4 °C
Exact Mass	177.115356
PSA	28.75000
LogP	1.25
Appearance	powder \| white
Vapor Pressure	0.0±0.6 mmHg at 25°C
Refractive Index	1.552
Additional Property	DMSO: soluble

Activity & Biological Data

Target	COX-2 Reactive oxygen species (ROS)
Additional Information	[1]. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10. [2]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57. [3]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 19;1448(1):77-84. [4]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec;222(3):236-45.

Target

COX-2 Reactive oxygen species (ROS)

Additional Information

[1]. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10. [2]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57. [3]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 19;1448(1):77-84. [4]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec;222(3):236-45.

Customs & Trade Information

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of N-tert-Butyl-α-phenylnitrone?

The CAS number of N-tert-Butyl-α-phenylnitrone is 3376-24-7.

What are the molecular formula and molecular weight of N-tert-Butyl-α-phenylnitrone?

N-tert-Butyl-α-phenylnitrone has molecular formula C11H15NO and molecular weight 177.243 g/mol.

What are the upstream and downstream products of N-tert-Butyl-α-phenylnitrone?

For N-tert-Butyl-α-phenylnitrone, Upstream Products: N-(tert-Butyl)benzylamine, Benzaldehyde, tert-Butylamine; Downstream Products: N-(tert-Butyl)benzylamine, Azo-tert-butane, N-Benzylidenemethylamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "N-tert-Butyl-α-phenylnitrone (CAS 3376-24-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-7895-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.