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Ethacrynic acid

Also known as: 2-[2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid, 2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxyacetic acid, Edecrin, Edecril, Edecrina, Endecril, Crinuryl, Hidromedin, Etacrynic acid, Etacrinic acid, Etakrinic acid, MK-595, NSC 85791, NSC 624008

Ethacrynic acid (CAS 58-54-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C13H12Cl2O4 and a molecular weight of 303.13800 g/mol. Key properties include a melting point of 125 °C, a boiling point of 480ºC at 760mmHg, a density of 1.35g/cm3 and a flash point of 244.1ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H312 — Harmful in contact with skin and H332 — Harmful if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
58-54-8
Jingsj CID
J-7869-3
Molecular Formula
C13H12Cl2O4
Molecular Weight
303.13800 g/mol
Category
Organic Acids
Last updated
8/21/2026
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Physicochemical Properties

Melting Point125 °C
Boiling Point480ºC at 760mmHg
Density1.35g/cm3
Flash Point244.1ºC
Exact Mass302.01100
PSA63.60000
LogP3.60570

GHS Safety & Compliance

IrritantSignal word: Warning
  • H302 — Harmful if swallowed
  • H312 — Harmful in contact with skin
  • H332 — Harmful if inhaled
  • H315 — Causes skin irritation
  • H319 — Causes serious eye irritation
  • H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information[1]. Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256. [2]. Harada T, et al. Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. Clinics (Sao Paulo). 2018 Oct 18;73:e332. [3]. Zhao XX, et al. Ethacrynic acid inhibits airway smooth muscle contraction in mice. Sheng Li Xue Bao. 2019 Dec 25;71(6):863-873. [4]. Byun HJ, et al. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. Biomol Ther (Seoul). 2013 Sep 30;21(5):338-42.

Frequently Asked Questions

What is the CAS number of Ethacrynic acid?

The CAS number of Ethacrynic acid is 58-54-8.

What are the molecular formula and molecular weight of Ethacrynic acid?

Ethacrynic acid has molecular formula C13H12Cl2O4 and molecular weight 303.13800 g/mol.

Is Ethacrynic acid hazardous?

Ethacrynic acid has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H312 — Harmful in contact with skin; H332 — Harmful if inhaled.

What are the upstream and downstream products of Ethacrynic acid?

For Ethacrynic acid, Upstream Products: Formaldehyde, 2,3-Dichlorophenol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Ethacrynic acid (CAS 58-54-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-7869-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.