Hemicholinium 3

Also known as: Hemicholinium-3, HC-3, Hemicholinium 3 dibromide, Hemicholinium bromide, Hemicholinium dibromide, 2,2'-(4,4'-biphenylylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide

Hemicholinium 3 (CAS 312-45-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C24H34Br2N2O4 and a molecular weight of 574.35 g/mol. Key property: a melting point of 180 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H311 — Toxic in contact with skin and H331 — Toxic if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 312-45-8
Jingsj CID: J-5023-7
Molecular Formula: C₂₄H₃₄Br₂N₂O₄
Molecular Weight: 574.35 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	180 °C
Exact Mass	572.08900
PSA	58.92000

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. PATRICE GUYENET, et al. Inhibition by Hemicholinium-3 of [ 14 C] Acetylcholine Synthesis and [ 3 H] Choline High-Affinity Uptake in Rat Striatal Synaptosomes.Molecular Pharmacology September 1973, 9 (5) 630-639. [2]. Péter Mandl, et al. Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons. Neurochem Int. 2006 Sep;49(4):327-33. [3]. Masato Inazu, et al. Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: a target molecule for lung cancer therapy. Pharmacol Res. 2013 Oct;76:119-31. [4]. T K Chatterjee, et al. Methylpiperidine analog of hemicholinium-3: a selective, high affinity non-competitive inhibitor of sodium dependent choline uptake system. Eur J Pharmacol. 1988 May 10;149(3):241-8. [5]. J J Hagan, et al. Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics. Psychopharmacology (Berl). 1989;98(3):347-56.

Additional Information

[1]. PATRICE GUYENET, et al. Inhibition by Hemicholinium-3 of [ 14 C] Acetylcholine Synthesis and [ 3 H] Choline High-Affinity Uptake in Rat Striatal Synaptosomes.Molecular Pharmacology September 1973, 9 (5) 630-639. [2]. Péter Mandl, et al. Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons. Neurochem Int. 2006 Sep;49(4):327-33. [3]. Masato Inazu, et al. Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: a target molecule for lung cancer therapy. Pharmacol Res. 2013 Oct;76:119-31. [4]. T K Chatterjee, et al. Methylpiperidine analog of hemicholinium-3: a selective, high affinity non-competitive inhibitor of sodium dependent choline uptake system. Eur J Pharmacol. 1988 May 10;149(3):241-8. [5]. J J Hagan, et al. Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics. Psychopharmacology (Berl). 1989;98(3):347-56.

Frequently Asked Questions

What is the CAS number of Hemicholinium 3?

The CAS number of Hemicholinium 3 is 312-45-8.

What are the molecular formula and molecular weight of Hemicholinium 3?

Hemicholinium 3 has molecular formula C24H34Br2N2O4 and molecular weight 574.35 g/mol.

Is Hemicholinium 3 hazardous?

Hemicholinium 3 has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H311 — Toxic in contact with skin; H331 — Toxic if inhaled.

What are the upstream and downstream products of Hemicholinium 3?

For Hemicholinium 3, Upstream Products: N,N-Dimethylethanolamine, 4,4'-Bis(2-bromoacetyl)biphenyl.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Hemicholinium 3 (CAS 312-45-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-5023-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.