Brefeldin A

Also known as: BFA, Cyanein, Decumbin, Ascotoxin, Nectrolide, Synergisidin, (1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone

Brefeldin A (CAS 20350-15-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C16H24O4 and a molecular weight of 280.359 g/mol. Key properties include a melting point of 200-205ºC, a boiling point of 492.7±45.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 180.8±22.2 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 20350-15-6
Jingsj CID: J-49926-3
Molecular Formula: C₁₆H₂₄O₄
Molecular Weight: 280.359 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	200-205ºC
Boiling Point	492.7±45.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	180.8±22.2 °C
Exact Mass	280.167450
PSA	66.76000
LogP	1.61
Vapor Pressure	0.0±2.8 mmHg at 25°C
Refractive Index	1.513
Storage Conditions	2-8℃

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	CRISPR/Cas9
Additional Information	[1]. Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14. [2]. Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9. [3]. Tseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19(11):17464-77. [4]. Wang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641. [5]. Yu C, et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 2015 Feb 5;16(2):142-7.

Target

CRISPR/Cas9

Additional Information

[1]. Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14. [2]. Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9. [3]. Tseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19(11):17464-77. [4]. Wang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641. [5]. Yu C, et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 2015 Feb 5;16(2):142-7.

Frequently Asked Questions

What is the CAS number of Brefeldin A?

The CAS number of Brefeldin A is 20350-15-6.

What are the molecular formula and molecular weight of Brefeldin A?

Brefeldin A has molecular formula C16H24O4 and molecular weight 280.359 g/mol.

Is Brefeldin A hazardous?

Brefeldin A has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Brefeldin A (CAS 20350-15-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49926-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.