Kynurenic acid
Also known as: 4-Hydroxy-2-quinolinecarboxylic acid, 4-Hydroxyquinoline-2-carboxylic acid, 4-Hydroxyquinaldic acid, 4-Hydroxyquinaldinic acid, 4-Oxo-1,4-dihydroquinoline-2-carboxylic acid, 1,4-Dihydro-4-oxoquinoline-2-carboxylic acid, 2-Carboxy-4-hydroxyquinoline, Quinurenic acid, NSC 58973
Kynurenic acid (CAS 492-27-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C10H7NO3 and a molecular weight of 189.167 g/mol. Key properties include a melting point of 275 °C (dec.)(lit.), a boiling point of 358.4±42.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 170.5±27.9 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 492-27-3
- Jingsj CID
- J-49405-3
- Molecular Formula
- C10H7NO3
- Molecular Weight
- 189.167 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 275 °C (dec.)(lit.) |
|---|---|
| Boiling Point | 358.4±42.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 170.5±27.9 °C |
| Exact Mass | 189.042587 |
| PSA | 70.42000 |
| LogP | 2.28 |
| Vapor Pressure | 0.0±0.8 mmHg at 25°C |
| Refractive Index | 1.639 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | Human Endogenous Metabolite |
|---|---|
| Additional Information | [1]. Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8. [2]. Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32. [3]. Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13. |
Frequently Asked Questions
What is the CAS number of Kynurenic acid?
The CAS number of Kynurenic acid is 492-27-3.
What are the molecular formula and molecular weight of Kynurenic acid?
Kynurenic acid has molecular formula C10H7NO3 and molecular weight 189.167 g/mol.
Is Kynurenic acid hazardous?
Kynurenic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of Kynurenic acid?
For Kynurenic acid, Upstream Products: DL-Kynurenine, L-Kynurenine, 2'-Nitroacetophenone; Downstream Products: leucoline, 4-Bromoquinoline-2-carboxylic acid, 4-Hydroxyquinoline.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Kynurenic acid (CAS 492-27-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-49405-3 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.