Etoricoxib

Also known as: 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine, Arcoxia, Algix, MK-0663, MK-663, Tauxib, Nucoxia, Etoricoxibe, UNII-WRX4NFY03R

Etoricoxib (CAS 202409-33-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H15ClN2O2S and a molecular weight of 358.842 g/mol. Key properties include a melting point of 134-135°C, a boiling point of 510.0±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 262.2±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed and H310. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 202409-33-4
Jingsj CID: J-48251-9
Molecular Formula: C₁₈H₁₅ClN₂O₂S
Molecular Weight: 358.842 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	134-135°C
Boiling Point	510.0±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	262.2±30.1 °C
Exact Mass	358.054260
PSA	68.30000
LogP	2.21
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.601
Storage Conditions	-20°C Freezer

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H302 — Harmful if swallowed
H310

Activity & Biological Data

Target	COX-2:1.1 μM (IC50, in human whole blood) COX-1:116 μM (IC50, in human whole blood)
Additional Information	[1]. Riendeau D, et al.Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther. 2001 Feb;296(2):558-66. [2]. Kunak CS, et al. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxid Med Cell Longev. 2015;2015:598162. [3]. Tanwar L, et al. Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis. Asian Pac J Cancer Prev. 2010;11(5):1329-33.

Target

COX-2:1.1 μM (IC50, in human whole blood) COX-1:116 μM (IC50, in human whole blood)

Additional Information

[1]. Riendeau D, et al.Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther. 2001 Feb;296(2):558-66. [2]. Kunak CS, et al. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxid Med Cell Longev. 2015;2015:598162. [3]. Tanwar L, et al. Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis. Asian Pac J Cancer Prev. 2010;11(5):1329-33.

Customs & Trade Information

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Etoricoxib?

The CAS number of Etoricoxib is 202409-33-4.

What are the molecular formula and molecular weight of Etoricoxib?

Etoricoxib has molecular formula C18H15ClN2O2S and molecular weight 358.842 g/mol.

Is Etoricoxib hazardous?

Etoricoxib has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H310.

What are the upstream and downstream products of Etoricoxib?

For Etoricoxib, Upstream Products: 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, 1-(6-Methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethanone, Methyl 6-methylnicotinate; Downstream Products: Etoricoxib N1'-oxide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Etoricoxib (CAS 202409-33-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-48251-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.