Ethyl 3,4-dihydroxybenzoate

Also known as: Ethyl protocatechuate, Protocatechuic acid ethyl ester, 3,4-Dihydroxybenzoic acid ethyl ester, EDHB, Benzoic acid, 3,4-dihydroxy-, ethyl ester, Ethyl-3,4-dihydroxybenzoate, MFCD00002199, NSC 86130, NSC 619681

Ethyl 3,4-dihydroxybenzoate (CAS 3943-89-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C9H10O4 and a molecular weight of 182.173 g/mol. Key properties include a melting point of 132-134 °C(lit.), a boiling point of 358.1±22.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 147.0±15.8 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. It is listed by 1 supplier; request a quote for pricing. Record last updated Aug 21, 2026.

CAS No.: 3943-89-3
Jingsj CID: J-48017-1
Molecular Formula: C₉H₁₀O₄
Molecular Weight: 182.173 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	132-134 °C(lit.)
Boiling Point	358.1±22.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	147.0±15.8 °C
Exact Mass	182.057907
PSA	66.76000
LogP	2.22
Vapor Pressure	0.0±0.8 mmHg at 25°C
Refractive Index	1.574

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204. [2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7. [3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84. [4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9.

Additional Information

[1]. Bo Han, et al. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One. 2014 Sep 18;9(9):e107204. [2]. Sebastian Philipp, et al. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H450-7. [3]. Byeong-Ju Kwon, et al. Ethyl-3,4-dihydroxybenzoate with a dual function of induction of osteogenic differentiation and inhibition of osteoclast differentiation for bone tissue engineering. Tissue Eng Part A. 2014 Nov;20(21-22):2975-84. [4]. D Nandan, et al. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. J Cell Biol. 1990 May;110(5):1673-9.

Customs & Trade Information

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Ethyl 3,4-dihydroxybenzoate?

The CAS number of Ethyl 3,4-dihydroxybenzoate is 3943-89-3.

What are the molecular formula and molecular weight of Ethyl 3,4-dihydroxybenzoate?

Ethyl 3,4-dihydroxybenzoate has molecular formula C9H10O4 and molecular weight 182.173 g/mol.

Which suppliers offer Ethyl 3,4-dihydroxybenzoate?

1 supplier(s) listed; request a quote for pricing.

Is Ethyl 3,4-dihydroxybenzoate hazardous?

Ethyl 3,4-dihydroxybenzoate has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Ethyl 3,4-dihydroxybenzoate?

For Ethyl 3,4-dihydroxybenzoate, Upstream Products: protocatechuic acid, Ethanol, Ethylparaben; Downstream Products: Methyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate, Ethyl 3,4-dimethoxybenzoate, 3,4-dihydroxybenzhydrazide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ethyl 3,4-dihydroxybenzoate (CAS 3943-89-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-48017-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.