Vadimezan

Also known as: DMXAA, ASA404, 5,6-Dimethylxanthenone-4-acetic acid, 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid, 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, 5,6-Dimethylxantheonone-4-acetic acid, AS1404

Vadimezan (CAS 117570-53-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H14O4 and a molecular weight of 282.291 g/mol. Key properties include a melting point of 264 °C, a boiling point of 520.9±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 197.1±23.6 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 117570-53-3
Jingsj CID: J-47975-4
Molecular Formula: C₁₇H₁₄O₄
Molecular Weight: 282.291 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	264 °C
Boiling Point	520.9±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	197.1±23.6 °C
Exact Mass	282.089203
PSA	67.51000
LogP	3.60
Appearance	solid \| light brown
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.633
Storage Conditions	2-8°C
Additional Property	DMSO: 17 mg/mL, soluble

GHS Safety & Compliance

Irritant / Environmental HazardSignal word: Warning

H302 — Harmful if swallowed
H400 — Very toxic to aquatic life

Activity & Biological Data

Target	STING[1], type I IFNs[2]
Additional Information	[1]. Downey CM, et al. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One. 2014 Jun 18;9(6):e99988. [2]. Shirey KA, et al. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo. J Leukoc Biol. 2011 Mar;89(3):351-7.

Target

STING[1], type I IFNs[2]

Additional Information

[1]. Downey CM, et al. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One. 2014 Jun 18;9(6):e99988. [2]. Shirey KA, et al. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo. J Leukoc Biol. 2011 Mar;89(3):351-7.

Customs & Trade Information

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Vadimezan?

The CAS number of Vadimezan is 117570-53-3.

What are the molecular formula and molecular weight of Vadimezan?

Vadimezan has molecular formula C17H14O4 and molecular weight 282.291 g/mol.

Is Vadimezan hazardous?

Vadimezan has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H400 — Very toxic to aquatic life.

What are the upstream and downstream products of Vadimezan?

For Vadimezan, Upstream Products: 2-(2-Carboxymethylphenoxy)-3,4-dimethylbenzoic acid, 6,7-dimethyl-1H-indole-2,3-dione, N-(2,3-dimethylphenyl)-2-hydroxyiminoacetamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vadimezan (CAS 117570-53-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-47975-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.