Folinic acid

Also known as: leucovorin, 5-formyl-5,6,7,8-tetrahydrofolate, 5-formyltetrahydrofolate, 5-formyltetrahydrofolic acid, N5-formyl-5,6,7,8-tetrahydrofolate, levoleucovorin, 5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid

Folinic acid (CAS 58-05-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C20H23N7O7 and a molecular weight of 473.43900 g/mol. Key properties include a melting point of 245ºC (decomp) and a density of 1.68g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 58-05-9
Jingsj CID: J-46967-0
Molecular Formula: C₂₀H₂₃N₇O₇
Molecular Weight: 473.43900 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	245ºC (decomp)
Density	1.68g/cm3
Exact Mass	473.16600
PSA	219.84000
LogP	1.15290
Refractive Index	1.748
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Goldman, I.D. and L.H. Matherly, Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. NCI Monogr, 1987(5): p. 17-26. [2]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.

Additional Information

[1]. Goldman, I.D. and L.H. Matherly, Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. NCI Monogr, 1987(5): p. 17-26. [2]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.

Frequently Asked Questions

What is the CAS number of Folinic acid?

The CAS number of Folinic acid is 58-05-9.

What are the molecular formula and molecular weight of Folinic acid?

Folinic acid has molecular formula C20H23N7O7 and molecular weight 473.43900 g/mol.

What are the upstream and downstream products of Folinic acid?

For Folinic acid, Upstream Products: Leucovorin calcium pentahydrate; Downstream Products: Folic Acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Folinic acid (CAS 58-05-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-46967-0 (accessed 2026-11-09).

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