Damnacanthal

Also known as: 2-Anthracenecarboxaldehyde, 9,10-dihydro-3-hydroxy-1-methoxy-9,10-dioxo-, 3-Hydroxy-1-methoxy-9,10-dioxo-9,10-dihydro-2-anthracenecarbaldehyde, 3-Hydroxy-1-methoxy-9,10-dioxo-9,10-dihydro-anthracene-2-carbaldehyde, 3-Hydroxy-1-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde, 3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde, 1-Methoxy-3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde, 2-Anthraquinonecarboxaldehyde, 3-hydroxy-1-methoxy-

Damnacanthal (CAS 477-84-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C16H10O5 and a molecular weight of 282.248 g/mol. Key properties include a boiling point of 531.9±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 204.9±23.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 477-84-9
Jingsj CID: J-4621-9
Molecular Formula: C₁₆H₁₀O₅
Molecular Weight: 282.248 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	531.9±50.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	204.9±23.6 °C
Exact Mass	282.052826
PSA	80.67000
LogP	3.74
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.692
Storage Conditions	2-8℃

Activity & Biological Data

Target	IC50: 46 nM (p56 lck autophosphorylation) and 220 nM (phosphorylation of exogenous substrates by p56 lck)[1]; Apoptosis[2]; Candida albicans[2]
Additional Information	[1]. Faltynek CR, et al. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Biochemistry. 1995 Sep 26;34(38):12404-10. [2]. Nualsanit T, et al. Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells. J Nutr Biochem. 2012 Aug;23(8):915-23. [3]. Aziz MY, et al. Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells. Oncol Lett. 2014 May;7(5):1479-1484. [4]. Okusada K, et al. The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia. Biol Pharm Bull. 2011;34(1):103-7.

Target

IC50: 46 nM (p56 lck autophosphorylation) and 220 nM (phosphorylation of exogenous substrates by p56 lck)[1]; Apoptosis[2]; Candida albicans[2]

Additional Information

[1]. Faltynek CR, et al. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Biochemistry. 1995 Sep 26;34(38):12404-10. [2]. Nualsanit T, et al. Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells. J Nutr Biochem. 2012 Aug;23(8):915-23. [3]. Aziz MY, et al. Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells. Oncol Lett. 2014 May;7(5):1479-1484. [4]. Okusada K, et al. The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia. Biol Pharm Bull. 2011;34(1):103-7.

Frequently Asked Questions

What is the CAS number of Damnacanthal?

The CAS number of Damnacanthal is 477-84-9.

What are the molecular formula and molecular weight of Damnacanthal?

Damnacanthal has molecular formula C16H10O5 and molecular weight 282.248 g/mol.

What are the upstream and downstream products of Damnacanthal?

For Damnacanthal, Upstream Products: Phthalic anhydride, Rubiadin, Damnacanthol; Downstream Products: Damnacanthol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Damnacanthal (CAS 477-84-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-4621-9 (accessed 2026-11-10).

Data for reference only; verify product details with suppliers before purchase.