N-Desmethylclozapine

Also known as: Norclozapine, Normethylclozapine, Desmethylclozapine, N-Demethylclozapine, 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, 8-Chloro-11-piperazin-1-yl-5H-dibenzo[b,e][1,4]diazepine, 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine, 8-Chloro-11-1[1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, 8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZEPINE, CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC, Demethylclozapine, N-desmethyl clozapine

N-Desmethylclozapine (CAS 6104-71-8) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C17H17ClN4 and a molecular weight of 312.79700 g/mol. Key properties include a melting point of 120-125°C, a boiling point of 490.1ºC at 760 mmHg, a density of 1.38g/cm3 and a flash point of 250.2ºC. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6104-71-8
Jingsj CID: J-45995-0
Molecular Formula: C₁₇H₁₇ClN₄
Molecular Weight: 312.79700 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	120-125°C
Boiling Point	490.1ºC at 760 mmHg
Density	1.38g/cm3
Flash Point	250.2ºC
Exact Mass	312.11400
PSA	39.66000
LogP	3.22080
Refractive Index	1.709
Storage Conditions	Store at RT

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H370 — Causes damage to organs

Activity & Biological Data

Additional Information	[1]. Medigeshi GR, et al. N-Desmethylclozapine, Fluoxetine and Salmeterol inhibit post-entry stages of dengue virus life-cycle. Antimicrob Agents Chemother. 2016 Aug 29. [2]. Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. J Psychopharmacol. 2016 Sep;30(9):896-912. [3]. Sugawara Y, et al. Electrophysiological evidence showing muscarinic agonist-antagonist activities of N-desmethylclozapine using hippocampal excitatory and inhibitory neurons. Brain Res. 2016 Jul 1;1642:255-62. [4]. Gigout S, et al. Different pharmacology of N-desmethylclozapine at human and rat M2 and M 4 mAChRs in neocortex. Naunyn Schmiedebergs Arch Pharmacol. 2015 May;388(5):487-96. [5]. Himmerich H, et al. Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro. Med Chem. 2012 Nov;8(6):1032-8.

Additional Information

[1]. Medigeshi GR, et al. N-Desmethylclozapine, Fluoxetine and Salmeterol inhibit post-entry stages of dengue virus life-cycle. Antimicrob Agents Chemother. 2016 Aug 29. [2]. Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. J Psychopharmacol. 2016 Sep;30(9):896-912. [3]. Sugawara Y, et al. Electrophysiological evidence showing muscarinic agonist-antagonist activities of N-desmethylclozapine using hippocampal excitatory and inhibitory neurons. Brain Res. 2016 Jul 1;1642:255-62. [4]. Gigout S, et al. Different pharmacology of N-desmethylclozapine at human and rat M2 and M 4 mAChRs in neocortex. Naunyn Schmiedebergs Arch Pharmacol. 2015 May;388(5):487-96. [5]. Himmerich H, et al. Impact of clozapine, N-desmethylclozapine and chlorpromazine on thromboxane production in vitro. Med Chem. 2012 Nov;8(6):1032-8.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of N-Desmethylclozapine?

The CAS number of N-Desmethylclozapine is 6104-71-8.

What are the molecular formula and molecular weight of N-Desmethylclozapine?

N-Desmethylclozapine has molecular formula C17H17ClN4 and molecular weight 312.79700 g/mol.

Is N-Desmethylclozapine hazardous?

N-Desmethylclozapine has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

What are the upstream and downstream products of N-Desmethylclozapine?

For N-Desmethylclozapine, Upstream Products: Piperazine, 8-Chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, Clozapine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "N-Desmethylclozapine (CAS 6104-71-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45995-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.