Physostigmine

Also known as: Eserine, Antilirium, (-)-Eserine, (3aS,8aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate, Physostigmine (USP), Cogmine, NSC 30782, Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-

Physostigmine (CAS 57-47-6) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C15H21N3O2 and a molecular weight of 275.346 g/mol. Key properties include a melting point of 102-104 °C(lit.), a boiling point of 422.3±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 209.2±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H300 and H330 — Fatal if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 57-47-6
Jingsj CID: J-45709-5
Molecular Formula: C₁₅H₂₁N₃O₂
Molecular Weight: 275.346 g/mol
Category: Organic Bases
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	102-104 °C(lit.)
Boiling Point	422.3±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	209.2±31.5 °C
Exact Mass	275.163391
PSA	44.81000
LogP	1.89
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.616

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H300
H330 — Fatal if inhaled

Activity & Biological Data

Additional Information	[1]. Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189. [2]. Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2005;181(1):145‐152. [3]. Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205.

Additional Information

[1]. Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189. [2]. Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2005;181(1):145‐152. [3]. Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205.

Frequently Asked Questions

What is the CAS number of Physostigmine?

The CAS number of Physostigmine is 57-47-6.

What are the molecular formula and molecular weight of Physostigmine?

Physostigmine has molecular formula C15H21N3O2 and molecular weight 275.346 g/mol.

Is Physostigmine hazardous?

Physostigmine has GHS signal word Danger and hazard statements H300; H330 — Fatal if inhaled.

What are the upstream and downstream products of Physostigmine?

For Physostigmine, Downstream Products: Methylurea, Ethyl N-methylcarbamate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Physostigmine (CAS 57-47-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45709-5 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.