N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide

Also known as: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide, N-methyl-N-(t-butyldimethylsilyl)trifluoroacetamide, N-[tert-Butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide, N-[Dimethyl(2-methyl-2-propanyl)silyl]-2,2,2-trifluoro-N-methylacetamide, Acetamide, N-[(1,1-dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methyl-, Acetamide, N-((1,1-dimethylethyl)dimethylsilyl)-2,2,2-trifluoro-N-methyl-, MTBSTFA, MBDSTFA

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (CAS 77377-52-7) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C9H18F3NOSi and a molecular weight of 241.326 g/mol. Key properties include a boiling point of 182.6±35.0 °C at 760 mmHg, a density of 1.0±0.1 g/cm3 and a flash point of 64.2±25.9 °C. It is classified under GHS with signal word Warning and hazard statements H226 — Flammable liquid and vapour, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 77377-52-7
Jingsj CID: J-45150-3
Molecular Formula: C₉H₁₈F₃NOSi
Molecular Weight: 241.326 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	182.6±35.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Flash Point	64.2±25.9 °C
Exact Mass	241.110977
PSA	20.31000
LogP	3.32
Vapor Pressure	0.8±0.3 mmHg at 25°C
Refractive Index	1.400
Additional Property	decomposes

GHS Safety & Compliance

Flammable / IrritantSignal word: Warning

H226 — Flammable liquid and vapour
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Frequently Asked Questions

What is the CAS number of N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide?

The CAS number of N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide is 77377-52-7.

What are the molecular formula and molecular weight of N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide?

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide has molecular formula C9H18F3NOSi and molecular weight 241.326 g/mol.

Is N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide hazardous?

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide has GHS signal word Warning and hazard statements H226 — Flammable liquid and vapour; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide?

For N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide, Upstream Products: N-Methyl-2,2,2-trifluoroacetamide, tert-Butyldimethylchlorosilane.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (CAS 77377-52-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-45150-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.