N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride

Also known as: TMPD dihydrochloride, N,N,N',N'-Tetramethyl-1,4-benzenediamine dihydrochloride, N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride, N,N,N',N'-Tetramethyl-p-phenylenediammonium dichloride, Tetramethyl-p-phenylenediamine dihydrochloride, Wurster's reagent dihydrochloride

N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride (CAS 637-01-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C10H18Cl2N2 and a molecular weight of 237.169 g/mol. Key properties include a melting point of 222-224 °C(lit.), a boiling point of 260.6ºC at 760 mmHg and a flash point of 104.9ºC. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 637-01-4
Jingsj CID: J-44634-4
Molecular Formula: C₁₀H₁₈Cl₂N₂
Molecular Weight: 237.169 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	222-224 °C(lit.)
Boiling Point	260.6ºC at 760 mmHg
Flash Point	104.9ºC
Exact Mass	236.084702
PSA	6.48000
LogP	3.42260
Additional Property	SOLUBLE

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation

Activity & Biological Data

Additional Information	[1]. S Kuss, et al. Electrochemical recognition and quantification of cytochrome c expression in Bacillus subtilis and aerobe/anaerobe Escherichia coli using N, N, N', N'-tetramethyl- para-phenylene-diamine (TMPD). Chem Sci. 2017 Nov 1;8(11):7682-7688. [2]. Nenad Petrovic, et al. Using N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) to assay cyclooxygenase activity in vitro. Methods Mol Biol. 2010;594:129-40. [3]. Franco A Rossato, et al. Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration. PLoS One. 2014 Jun 25;9(6):e101060.

Additional Information

[1]. S Kuss, et al. Electrochemical recognition and quantification of cytochrome c expression in Bacillus subtilis and aerobe/anaerobe Escherichia coli using N, N, N', N'-tetramethyl- para-phenylene-diamine (TMPD). Chem Sci. 2017 Nov 1;8(11):7682-7688. [2]. Nenad Petrovic, et al. Using N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) to assay cyclooxygenase activity in vitro. Methods Mol Biol. 2010;594:129-40. [3]. Franco A Rossato, et al. Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration. PLoS One. 2014 Jun 25;9(6):e101060.

Customs & Trade Information

HS Code	2921519090
Summary	2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride?

The CAS number of N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride is 637-01-4.

What are the molecular formula and molecular weight of N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride?

N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride has molecular formula C10H18Cl2N2 and molecular weight 237.169 g/mol.

Is N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride hazardous?

N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride (CAS 637-01-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-44634-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.