2-Hydroxychalcone

Also known as: (E)-3-(2-Hydroxyphenyl)-1-phenylprop-2-en-1-one, Benzylidene-2-hydroxyacetophenone, Salicylalacetophenone, 2-(2-Hydroxybenzylidene)acetophenone, 2-Hydroxybenzalacetophenone, 2-Hydroxybenzylidene acetophenone, 3-(2-Hydroxyphenyl)-1-phenyl-2-propen-1-one, HYDROXYCHALCONE, 2-, EINECS 211-422-1, MFCD00016449

2-Hydroxychalcone (CAS 644-78-0) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C15H12O2 and a molecular weight of 224.25500 g/mol. Key properties include a melting point of 144-150ºC(lit.), a boiling point of 396.566ºC at 760 mmHg, a density of 1.191g/cm3 and a flash point of 169.35ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 644-78-0
Jingsj CID: J-43522-3
Molecular Formula: C₁₅H₁₂O₂
Molecular Weight: 224.25500 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	144-150ºC(lit.)
Boiling Point	396.566ºC at 760 mmHg
Density	1.191g/cm3
Flash Point	169.35ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Refractive Index	1.654

Activity & Biological Data

Additional Information	[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

Additional Information

[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

Customs & Trade Information

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 2-Hydroxychalcone?

The CAS number of 2-Hydroxychalcone is 644-78-0.

What are the molecular formula and molecular weight of 2-Hydroxychalcone?

2-Hydroxychalcone has molecular formula C15H12O2 and molecular weight 224.25500 g/mol.

What are the upstream and downstream products of 2-Hydroxychalcone?

For 2-Hydroxychalcone, Upstream Products: Salicylaldehyde, Acetophenone, 2-Methylbenzyl Alcohol; Downstream Products: 1-(2-Hydroxyphenyl)-3-phenylpropan-1-one, Flavanone, 3-Hydroxy-2-phenylchroman-4-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-Hydroxychalcone (CAS 644-78-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-43522-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.