Nα-p-Tosyl-L-arginine methyl ester hydrochloride

Also known as: TAME hydrochloride, Tos-Arg-OMe·HCl, Nalpha-Tosyl-L-arginine methyl ester hydrochloride, Nα-Tosyl-L-arginine methyl ester hydrochloride, Nalpha-p-toluenesulfonyl-L-arginine methyl ester hydrochloride, N-4-Tosyl-L-arginine methyl ester hydrochloride, methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate hydrochloride, (S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate hydrochloride, tos-arg-ome.hcl, Nalpha-4-Tosyl-L-arginine methyl ester hydrochloride

Nα-p-Tosyl-L-arginine methyl ester hydrochloride (CAS 1784-03-8) is a compound in the Solvents category listed in the Jingsj chemical database. It has the molecular formula C14H23ClN4O4S and a molecular weight of 378.875 g/mol. Key properties include a melting point of 145-147(lit.), a boiling point of 544.1ºC at 760mmHg and a flash point of 282.9ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1784-03-8
Jingsj CID: J-43164-1
Molecular Formula: C₁₄H₂₃ClN₄O₄S
Molecular Weight: 378.875 g/mol
Category: Solvents
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	145-147(lit.)
Boiling Point	544.1ºC at 760mmHg
Flash Point	282.9ºC
Exact Mass	378.112854
PSA	142.75000
LogP	3.54280
Vapor Pressure	6.73E-12mmHg at 25°C
Refractive Index	-14 ° (C=4, H2O)

Activity & Biological Data

Target	APC [1].
Additional Information	[1]. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [2]. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. [3]. Ma Y, et al. Differential effects of Mg(ii) and N(alpha)-4-tosyl-l-arginine methyl ester hydrochloride on the recognition and catalysis in ATP hydrolysis. Dalton Trans. 2008 Feb 28;(8):1081-6.

Target

APC [1].

Additional Information

[1]. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [2]. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. [3]. Ma Y, et al. Differential effects of Mg(ii) and N(alpha)-4-tosyl-l-arginine methyl ester hydrochloride on the recognition and catalysis in ATP hydrolysis. Dalton Trans. 2008 Feb 28;(8):1081-6.

Customs & Trade Information

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of Nα-p-Tosyl-L-arginine methyl ester hydrochloride?

The CAS number of Nα-p-Tosyl-L-arginine methyl ester hydrochloride is 1784-03-8.

What are the molecular formula and molecular weight of Nα-p-Tosyl-L-arginine methyl ester hydrochloride?

Nα-p-Tosyl-L-arginine methyl ester hydrochloride has molecular formula C14H23ClN4O4S and molecular weight 378.875 g/mol.

What are the upstream and downstream products of Nα-p-Tosyl-L-arginine methyl ester hydrochloride?

For Nα-p-Tosyl-L-arginine methyl ester hydrochloride, Upstream Products: L-Arginine, p-Toluenesulfonyl chloride, Methanol; Downstream Products: Tos-Arg-NH2 hydrochloride, Nα-Tosyl-L-arginine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nα-p-Tosyl-L-arginine methyl ester hydrochloride (CAS 1784-03-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-43164-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.